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10.1177/10781552251403953 http://scihub22266oqcxt.onion/10.1177/10781552251403953 41359156!?!41359156 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41359156&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Oncol+Pharm+Pract 2025 ; ? (?): 10781552251403953 Nephropedia Template TP {{tp|p=41359156|t=2025. Revisiting predictors of high-dose methotrexate related severe nephrotoxicity in children with acute lymphoblastic leukemia |pdf=|usr=}}{{41359156}} gab.com Text Revisiting predictors of high-dose methotrexate related severe nephrotoxicity in children with acute lymphoblastic leukemia JO: J Oncol Pharm Pract http://www.kidney.de/pget.php?&tw=1&pmid=41359156 #FOAvip IntroductionAcute lymphoblastic leukemia (ALL) is the most common childhood cancer, and high-dose methotrexate (HDMTX) is a key chemotherapeutic agent. HDMTX can cause nephrotoxicity. This study aimed to identify prognostic indicators of HDMTX-related severe nephrotoxicity in children with ALL.MethodsA retrospective review of children with ALL treated at Chiang Mai University Hospital (2016-2020) was conducted. Demographic, clinical, and treatment-related factors associated with HDMTX-related severe nephrotoxicity were analyzed using multivariable multilevel logistic regression, reported as adjusted odds ratio (aOR).ResultsA total of 61 children with ALL underwent 243 HDMTX infusion cycles. HDMTX-related severe nephrotoxicity occurred in 37.7% (23/61) of patients and 12.3% (30/243) of infusion cycles. No significant differences in baseline characteristics were observed. Concurrent amikacin use was an independent risk factor (aOR = 17.693 [1.613-194.032] P = 0.019), while higher baseline urine pH was protective (aOR = 0.190 [0.082-0.440] P < 0.001). A baseline urine pH < 7.0 was identified as the optimal cutoff for predicting HDMTX-related severe nephrotoxicity (area under the ROC curve = 0.72 [0.63-0.81]). All nephrotoxic events resolved completely.ConclusionsConcurrent amikacin use and low baseline urine pH are significant predictors of HDMTX-related severe nephrotoxicity in children with ALL. Identification of these factors is crucial for preventing nephrotoxicity. Twit Text FOAVip Revisiting predictors of high-dose methotrexate related severe nephrotoxicity in children with acute lymphoblastic leukemia ????J Oncol Pharm Pract http://www.kidney.de/pget.php?&tw=1&pmid=41359156 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41359156 #FOAvip English Wikipedia <ref>{{Cite pmid|41359156}}</ref> Revisiting predictors of high-dose methotrexate related severe nephrotoxicity in children with acute lymphoblastic leukemia #MMPMID41359156 Choed-Amphai C; Khorana J; Sathitsamitphong L; Maneekesorn S; Chanthong S; Natesirinilkul R; Charoenkwan P J Oncol Pharm Pract 2025[Dec]; ? (?): 10781552251403953 PMID41359156show ga IntroductionAcute lymphoblastic leukemia (ALL) is the most common childhood cancer, and high-dose methotrexate (HDMTX) is a key chemotherapeutic agent. HDMTX can cause nephrotoxicity. This study aimed to identify prognostic indicators of HDMTX-related severe nephrotoxicity in children with ALL.MethodsA retrospective review of children with ALL treated at Chiang Mai University Hospital (2016-2020) was conducted. Demographic, clinical, and treatment-related factors associated with HDMTX-related severe nephrotoxicity were analyzed using multivariable multilevel logistic regression, reported as adjusted odds ratio (aOR).ResultsA total of 61 children with ALL underwent 243 HDMTX infusion cycles. HDMTX-related severe nephrotoxicity occurred in 37.7% (23/61) of patients and 12.3% (30/243) of infusion cycles. No significant differences in baseline characteristics were observed. Concurrent amikacin use was an independent risk factor (aOR = 17.693 [1.613-194.032] P = 0.019), while higher baseline urine pH was protective (aOR = 0.190 [0.082-0.440] P < 0.001). A baseline urine pH < 7.0 was identified as the optimal cutoff for predicting HDMTX-related severe nephrotoxicity (area under the ROC curve = 0.72 [0.63-0.81]). All nephrotoxic events resolved completely.ConclusionsConcurrent amikacin use and low baseline urine pH are significant predictors of HDMTX-related severe nephrotoxicity in children with ALL. Identification of these factors is crucial for preventing nephrotoxicity. ?Revisiting predictors of high-dose methotrexate related severe nephrot(epmc).pdf DeepDyve Pubget Overpricing