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10.1002/jcsm.70157 http://scihub22266oqcxt.onion/10.1002/jcsm.70157 41355722!?!41355722       J+Cachexia+Sarcopenia+Muscle 2025 ; 16 (6): e70157 Nephropedia Template TP {{tp|p=41355722|t=2025. Thoracic Skeletal Muscle and Exercise Capacity in Adults With Congenital Heart Disease: A Cross-Sectional Imaging Analysis |pdf=|usr=}}{{41355722}} gab.com Text Thoracic Skeletal Muscle and Exercise Capacity in Adults With Congenital Heart Disease: A Cross-Sectional Imaging Analysis JO: J Cachexia Sarcopenia Muscle http://www.kidney.de/pget.php?&tw=1&pmid=41355722 #FOAvip BACKGROUND: The growing population of adults with congenital heart disease (ACHD) faces lifelong morbidities despite advancements in medical and surgical care. Sarcopenia, characterized by loss of muscle mass and strength, is linked to increased disability, poor quality of life and mortality. This study examines sex-specific thoracic skeletal muscle characteristics in ACHD patients using advanced imaging techniques, comparing them with healthy reference values and investigating their association with exercise capacity. MATERIAL AND METHODS: In this single-centre retrospective study, ACHD patients (age 18-50 years) who underwent both cardiopulmonary exercise tests and thoracic CT/MRI within a year were included. Skeletal muscle area (SMA) was manually measured and compared with healthy reference data. RESULTS: Among 60 ACHD patients (mean age 28.3 +/- 8.3 years; 48% females), males exhibited significantly lower SMA (T10: 116.8 +/- 24.6 cm(2), p < 0.0001; T11: 114.4 +/- 24.7 cm(2), p = 0.0002) and skeletal muscle index (SMI) (T10: 37.2 +/- 8 cm(2)/m(2), p = 0.005; T11: 36.4 +/- 8.1 cm(2)/m(2), p = 0.0014) at T10 and T11 vertebral level, whereas females showed a reduction in SMA at T10 (79.7 +/- 14.9 cm(2), p = 0.0242) and T12 (74.2 +/- 10.7 cm(2), p = 0.0015) compared with healthy individuals. Females had significantly lower skeletal muscle radiation attenuation (SMRA) at T10 (16.3 +/- 14.6 HU, p < 0.001), T11 (17.1 +/- 10.3 HU, p < 0.001) and T12 (25 +/- 10.7 HU, p < 0.001) levels, suggesting increased muscle fat content. Peak O(2) pulse correlated with SMA at T10 (r = 0.57, R(2) = 0.32, p </= 0.0001), T11 (r = 0.61, R(2) = 0.38, p < 0.0001) and T12 (r = 0.73, R(2) = 0.53, p = 0.001) levels. Similar correlations were observed between peak O(2) pulse and SMI, whereas peak VO(2) correlated with SMA at T10 (r = 0.27, R(2) = 0.07, p = 0.0394) and T11 (r = 0.34, R(2) = 0.11, p = 0.02) and SMRA across all levels (T10: r = 0.64, R(2) = 0.41, p = 0.0076; T11: r = 0.85, R(2) = 0.72, p = 0.0003; T12: r = 0.62, R(2) = 0.38, p = 0.0327). SMA at T11 had a negative correlation with VE/VCO(2) (r = -0.36, R(2) = 0.13, p = 0.01). There was no correlation between the number of sternotomies and exercise parameters. Subjects with a pacemaker demonstrated significantly lower peak VO(2) (p = 0.04) and VO(2) at the anabolic threshold (p = 0.03) compared with ACHD patients without a pacemaker. CONCLUSIONS: Abnormal skeletal muscle parameters observed on thoracic cross-sectional imaging are associated with diminished exercise capacity in ACHD patients. Assessment of thoracic skeletal muscle characteristics may enable early detection of muscle loss, providing valuable insights into the complex factors contributing to exercise limitations in this population. Twit Text FOAVip Thoracic Skeletal Muscle and Exercise Capacity in Adults With Congenital Heart Disease: A Cross-Sectional Imaging Analysis ????J Cachexia Sarcopenia Muscle http://www.kidney.de/pget.php?&tw=1&pmid=41355722 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41355722 #FOAvip English Wikipedia <ref>{{Cite pmid|41355722}}</ref> Thoracic Skeletal Muscle and Exercise Capacity in Adults With Congenital Heart Disease: A Cross-Sectional Imaging Analysis #MMPMID41355722 Steffen JD; Garton S; Ashwath R; Maldonado JR; Young K; Lancial C; Aldoss O; Porayette P J Cachexia Sarcopenia Muscle 2025[Dec]; 16 (6): e70157 PMID41355722show ga BACKGROUND: The growing population of adults with congenital heart disease (ACHD) faces lifelong morbidities despite advancements in medical and surgical care. Sarcopenia, characterized by loss of muscle mass and strength, is linked to increased disability, poor quality of life and mortality. This study examines sex-specific thoracic skeletal muscle characteristics in ACHD patients using advanced imaging techniques, comparing them with healthy reference values and investigating their association with exercise capacity. MATERIAL AND METHODS: In this single-centre retrospective study, ACHD patients (age 18-50 years) who underwent both cardiopulmonary exercise tests and thoracic CT/MRI within a year were included. Skeletal muscle area (SMA) was manually measured and compared with healthy reference data. RESULTS: Among 60 ACHD patients (mean age 28.3 +/- 8.3 years; 48% females), males exhibited significantly lower SMA (T10: 116.8 +/- 24.6 cm(2), p < 0.0001; T11: 114.4 +/- 24.7 cm(2), p = 0.0002) and skeletal muscle index (SMI) (T10: 37.2 +/- 8 cm(2)/m(2), p = 0.005; T11: 36.4 +/- 8.1 cm(2)/m(2), p = 0.0014) at T10 and T11 vertebral level, whereas females showed a reduction in SMA at T10 (79.7 +/- 14.9 cm(2), p = 0.0242) and T12 (74.2 +/- 10.7 cm(2), p = 0.0015) compared with healthy individuals. Females had significantly lower skeletal muscle radiation attenuation (SMRA) at T10 (16.3 +/- 14.6 HU, p < 0.001), T11 (17.1 +/- 10.3 HU, p < 0.001) and T12 (25 +/- 10.7 HU, p < 0.001) levels, suggesting increased muscle fat content. Peak O(2) pulse correlated with SMA at T10 (r = 0.57, R(2) = 0.32, p |*Exercise Tolerance[MESH] |*Heart Defects, Congenital/physiopathology/diagnostic imaging/complications[MESH] |*Muscle, Skeletal/diagnostic imaging/physiopathology[MESH] |Adolescent[MESH] |Adult[MESH] |Cross-Sectional Studies[MESH] |Exercise Test[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Retrospective Studies[MESH]Thoracic Skeletal Muscle and Exercise Capacity in Adults With Congenit(epmc).pdf DeepDyve Pubget Overpricing