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10.1002/advs.202409341 http://scihub22266oqcxt.onion/10.1002/advs.202409341 41355615!?!41355615       Adv+Sci+(Weinh) 2025 ; ? (?): e09341 Nephropedia Template TP {{tp|p=41355615|t=2025. Phase-Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer |pdf=|usr=}}{{41355615}} gab.com Text Phase-Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer JO: Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=41355615 #FOAvip Aberrant mitosis is a hallmark of cancer, which drives chromosomal instability, gene dysregulation, tumor heterogeneity, immune evasion, and therapy resistance. In this study, it is observed that dysregulation of YAP signaling can cause supernumerary centrosome clustering, thereby triggering pseudo-bipolar/multipolar diversion during anaphase in breast cancer. Mechanistically, the YAP can accumulate and hyperactivate the super-enhancer of the spindle assembly checkpoint, AJUBA, in a phase-separation-dependent manner, thus leading to aberrant mitosis. These findings reveal a crucial biological role of YAP-mediated super enhancer activation and provide new insights into aneuploidy formation in breast cancer. Twit Text FOAVip Phase-Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer ????Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=41355615 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41355615 #FOAvip English Wikipedia <ref>{{Cite pmid|41355615}}</ref> Phase-Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer #MMPMID41355615 Zhang R; Huang Q; Chen Z; Meng W; Dong H; Qi Z; Liu L; Shen J; Xie D Adv Sci (Weinh) 2025[Dec]; ? (?): e09341 PMID41355615show ga Aberrant mitosis is a hallmark of cancer, which drives chromosomal instability, gene dysregulation, tumor heterogeneity, immune evasion, and therapy resistance. In this study, it is observed that dysregulation of YAP signaling can cause supernumerary centrosome clustering, thereby triggering pseudo-bipolar/multipolar diversion during anaphase in breast cancer. Mechanistically, the YAP can accumulate and hyperactivate the super-enhancer of the spindle assembly checkpoint, AJUBA, in a phase-separation-dependent manner, thus leading to aberrant mitosis. These findings reveal a crucial biological role of YAP-mediated super enhancer activation and provide new insights into aneuploidy formation in breast cancer. ?Phase-Separation of YAP Mediates AJUBA Super Enhancer Activation to Pr(epmc).pdf DeepDyve Pubget Overpricing