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10.1038/s43856-025-01275-x http://scihub22266oqcxt.onion/10.1038/s43856-025-01275-x 41354904!?!41354904 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41354904&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Commun+Med+(Lond) 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41354904|t=2025. Hematologic and solid-organ malignancy risk in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis |pdf=|usr=}}{{41354904}} gab.com Text Hematologic and solid-organ malignancy risk in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis JO: Commun Med (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=41354904 #FOAvip BACKGROUND: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease characterized by small- and medium-vessel inflammation. Although chronic immune dysregulation and cytotoxic therapy exposure have been hypothesized to increase malignancy risk, large-scale, real-world evidence quantifying these risks has been limited. This study aimed to characterize hematologic and solid-organ malignancy risk profiles in patients with AAV using a large, multi-institutional database. METHODS: We conducted a retrospective cohort study using the TriNetX Research Network, using de-identified electronic medical record data from 2014 to 2024. We identified 19,238 patients with AAV and performed 1:1 propensity score matching to seborrheic keratosis controls on demographic and clinical covariates, yielding 18,255 matched pairs. Five-year incidences of hematologic and solid-organ malignancies were compared using hazard ratios (HR) and 95% confidence intervals (95% CI) from Cox proportional hazards regressions. RESULTS: Here we show that patients with AAV have a significantly increased risk of overall cancer (HR 1.23; 95% CI 1.12-1.35), driven by higher rates of hematologic malignancies (HR 2.12; 95% CI 1.77-2.53) and specific solid-organ cancers including lung (HR 1.78), bladder (HR 1.99), brain (HR 2.22), and lip/oral cavity/pharyngeal cancers (HR 1.78). Myelodysplastic syndromes (HR 4.11) and leukemia (HR 2.72) show the strongest associations. Negative controls show no risk elevation. CONCLUSIONS: Patients with AAV face distinct and heightened risks for select hematologic and solid-organ malignancies, supporting the need for tailored cancer surveillance strategies. These findings provide a large-scale, real-world evidence base for malignancy risk stratification and proactive screening in AAV. Twit Text FOAVip Hematologic and solid-organ malignancy risk in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis ????Commun Med (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=41354904 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41354904 #FOAvip English Wikipedia <ref>{{Cite pmid|41354904}}</ref> Hematologic and solid-organ malignancy risk in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis #MMPMID41354904 Mahajan A; Moslehi D; Bates DW Commun Med (Lond) 2025[Dec]; ? (?): ? PMID41354904show ga BACKGROUND: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease characterized by small- and medium-vessel inflammation. Although chronic immune dysregulation and cytotoxic therapy exposure have been hypothesized to increase malignancy risk, large-scale, real-world evidence quantifying these risks has been limited. This study aimed to characterize hematologic and solid-organ malignancy risk profiles in patients with AAV using a large, multi-institutional database. METHODS: We conducted a retrospective cohort study using the TriNetX Research Network, using de-identified electronic medical record data from 2014 to 2024. We identified 19,238 patients with AAV and performed 1:1 propensity score matching to seborrheic keratosis controls on demographic and clinical covariates, yielding 18,255 matched pairs. Five-year incidences of hematologic and solid-organ malignancies were compared using hazard ratios (HR) and 95% confidence intervals (95% CI) from Cox proportional hazards regressions. RESULTS: Here we show that patients with AAV have a significantly increased risk of overall cancer (HR 1.23; 95% CI 1.12-1.35), driven by higher rates of hematologic malignancies (HR 2.12; 95% CI 1.77-2.53) and specific solid-organ cancers including lung (HR 1.78), bladder (HR 1.99), brain (HR 2.22), and lip/oral cavity/pharyngeal cancers (HR 1.78). Myelodysplastic syndromes (HR 4.11) and leukemia (HR 2.72) show the strongest associations. Negative controls show no risk elevation. CONCLUSIONS: Patients with AAV face distinct and heightened risks for select hematologic and solid-organ malignancies, supporting the need for tailored cancer surveillance strategies. These findings provide a large-scale, real-world evidence base for malignancy risk stratification and proactive screening in AAV. ?Hematologic and solid-organ malignancy risk in antineutrophil cytoplas(epmc).pdf DeepDyve Pubget Overpricing