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10.1038/s42003-025-09171-9 http://scihub22266oqcxt.onion/10.1038/s42003-025-09171-9 41354833!?!41354833 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41354833&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Commun+Biol 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41354833|t=2025. Medium-chain triglycerides and ketogenic diet prevent alterations of the gut microbiome in transgenic Alzheimer s disease mice |pdf=|usr=}}{{41354833}} gab.com Text Medium-chain triglycerides and ketogenic diet prevent alterations of the gut microbiome in transgenic Alzheimer s disease mice JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=41354833 #FOAvip The systemic mechanisms underlying the benefits of ketogenic interventions on cognition in Alzheimer's disease (AD) are understudied. Interventions involving a carbohydrate-free high-fat ketogenic diet (KD) or dietary supplementation with medium-chain triglycerides (MCT) both improve cognition in AD mouse models, yet with opposing effects on circulating ketones levels, peripheral insulin sensitivity and inflammation. Since the gut microbiome regulates systemic metabolism and inflammation and is altered by aging and disease, we investigated how it is affected in mice subjected to MCT and KD. At early stages of pathology, AD mice exhibited substantially reduced richness and distinct composition of gut microbiome species. Administration of MCT or KD for 1-month increased microbiome diversity, restoring the levels of more than 50% of the bacteria altered in AD mice and inducing novel alterations. Both diets increased levels of short-chain fatty acid-producing bacteria, such as Lachnospiraceae, which directly correlated with improved hippocampal dendritic spine density. Interestingly, longer term administration of KD increased the obesity-associated Firmicutes/Bacteroidota ratio and bodyweight in AD but not WT mice, suggesting that AD-associated metabolic defects should be considered when designing such intervention. We conclude that MCT and KD may influence AD central and peripheral defects in part via modulation of the gut microbiome. Twit Text FOAVip Medium-chain triglycerides and ketogenic diet prevent alterations of the gut microbiome in transgenic Alzheimer s disease mice ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=41354833 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41354833 #FOAvip English Wikipedia <ref>{{Cite pmid|41354833}}</ref> Medium-chain triglycerides and ketogenic diet prevent alterations of the gut microbiome in transgenic Alzheimer s disease mice #MMPMID41354833 M'Bra PEH; Suarez-Uribe I; Avino M; Ng Kwan Lim E; Mayhue M; Balthazar P; Aumont A; Prevost K; Masse E; Fernandes KJL Commun Biol 2025[Dec]; ? (?): ? PMID41354833show ga The systemic mechanisms underlying the benefits of ketogenic interventions on cognition in Alzheimer's disease (AD) are understudied. Interventions involving a carbohydrate-free high-fat ketogenic diet (KD) or dietary supplementation with medium-chain triglycerides (MCT) both improve cognition in AD mouse models, yet with opposing effects on circulating ketones levels, peripheral insulin sensitivity and inflammation. Since the gut microbiome regulates systemic metabolism and inflammation and is altered by aging and disease, we investigated how it is affected in mice subjected to MCT and KD. At early stages of pathology, AD mice exhibited substantially reduced richness and distinct composition of gut microbiome species. Administration of MCT or KD for 1-month increased microbiome diversity, restoring the levels of more than 50% of the bacteria altered in AD mice and inducing novel alterations. Both diets increased levels of short-chain fatty acid-producing bacteria, such as Lachnospiraceae, which directly correlated with improved hippocampal dendritic spine density. Interestingly, longer term administration of KD increased the obesity-associated Firmicutes/Bacteroidota ratio and bodyweight in AD but not WT mice, suggesting that AD-associated metabolic defects should be considered when designing such intervention. We conclude that MCT and KD may influence AD central and peripheral defects in part via modulation of the gut microbiome. ?Medium-chain triglycerides and ketogenic diet prevent alterations of t(epmc).pdf DeepDyve Pubget Overpricing