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10.1038/s41526-025-00548-y http://scihub22266oqcxt.onion/10.1038/s41526-025-00548-y 41354651!?!41354651 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41354651&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       NPJ+Microgravity 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41354651|t=2025. Staphylococcal enterotoxin C2 rescued simulated microgravity-induced bone loss and the trans-differentiation of BMSCs into adipocytes |pdf=|usr=}}{{41354651}} gab.com Text Staphylococcal enterotoxin C2 rescued simulated microgravity-induced bone loss and the trans-differentiation of BMSCs into adipocytes JO: NPJ Microgravity http://www.kidney.de/pget.php?&tw=1&pmid=41354651 #FOAvip Exposure to microgravity decreases bone volume and increases marrow fat, partly due to impaired BMSC osteogenesis and enhanced adipogenesis. Staphylococcal enterotoxin C2 (SEC2) can influence BMSC differentiation, potentially promoting osteogenesis. This study investigated SEC2's effects on bone loss and marrow fat in hindlimb suspension (HLS) mice and BMSC differentiation under simulated microgravity. Results showed SEC2 alleviated bone deterioration and reduced marrow adiposity, promoting osteogenic over adipogenic differentiation by activating ERK/beta-catenin signaling pathways. SEC2 increased ERK phosphorylation and beta-catenin nuclear translocation, with effects diminished upon beta-catenin knockdown. These findings reveal a novel mechanism by which SEC2 modulates BMSC fate under microgravity, highlighting its potential as a therapeutic agent for preventing bone loss and marrow adiposity in microgravity conditions. Twit Text FOAVip Staphylococcal enterotoxin C2 rescued simulated microgravity-induced bone loss and the trans-differentiation of BMSCs into adipocytes ????NPJ Microgravity http://www.kidney.de/pget.php?&tw=1&pmid=41354651 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41354651 #FOAvip English Wikipedia <ref>{{Cite pmid|41354651}}</ref> Staphylococcal enterotoxin C2 rescued simulated microgravity-induced bone loss and the trans-differentiation of BMSCs into adipocytes #MMPMID41354651 Hou N; Yang Z; Wang H; Lu X; Bai S; Wang Y; Lin S; Tortorella MD; Feng L; Li G NPJ Microgravity 2025[Dec]; ? (?): ? PMID41354651show ga Exposure to microgravity decreases bone volume and increases marrow fat, partly due to impaired BMSC osteogenesis and enhanced adipogenesis. Staphylococcal enterotoxin C2 (SEC2) can influence BMSC differentiation, potentially promoting osteogenesis. This study investigated SEC2's effects on bone loss and marrow fat in hindlimb suspension (HLS) mice and BMSC differentiation under simulated microgravity. Results showed SEC2 alleviated bone deterioration and reduced marrow adiposity, promoting osteogenic over adipogenic differentiation by activating ERK/beta-catenin signaling pathways. SEC2 increased ERK phosphorylation and beta-catenin nuclear translocation, with effects diminished upon beta-catenin knockdown. These findings reveal a novel mechanism by which SEC2 modulates BMSC fate under microgravity, highlighting its potential as a therapeutic agent for preventing bone loss and marrow adiposity in microgravity conditions. ?Staphylococcal enterotoxin C2 rescued simulated microgravity-induced b(epmc).pdf DeepDyve Pubget Overpricing