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10.1021/acs.analchem.5c05432 http://scihub22266oqcxt.onion/10.1021/acs.analchem.5c05432 41353665!?!41353665 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41353665&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Anal+Chem 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41353665|t=2025. In Vivo Solid-Phase Microextraction with Palladium-Doped Covalent Organic Framework-Coated Fiber for Enhanced Nicotine-Associated Metabolite Detection in Rat Brain Regions |pdf=|usr=}}{{41353665}} gab.com Text In Vivo Solid-Phase Microextraction with Palladium-Doped Covalent Organic Framework-Coated Fiber for Enhanced Nicotine-Associated Metabolite Detection in Rat Brain Regions JO: Anal Chem http://www.kidney.de/pget.php?&tw=1&pmid=41353665 #FOAvip Nicotine's neuroactive properties and influence on brain metabolism are not widely explored, particularly in spatially resolved contexts. This technical note presents an in vivo solid-phase microextraction method coupled with UHPLC-TOF/MS to investigate the temporo-spatial distribution of nicotine-associated metabolites in rat brain regions. The coating material, a Palladium-doped covalent organic framework (I-TFBPT-COF@Pd), exhibited a large surface area, suitable pore diameter, and good biocompatibility. The metabolite distribution pattern spectra demonstrated SPME's superior adsorption performance, as evidenced by a broader and more uniform distribution of metabolites. Principal component analysis and orthogonal partial least-squares discriminant analysis indicated that nicotine exposure induced a profound alteration in the metabolite composition of the experimental samples. In addition, 46 differential metabolites and 7 key pathways in the hippocampus and striatum were identified, which revealed the range of nicotine's influence on various biochemical processes, including neurotransmitter synthesis, energy metabolism, and inflammation regulation. This method provides an effective way to study the potential neural effects of nicotine in the brain, surpassing traditional sampling techniques, and it has broad application prospects in biomedicine. Twit Text FOAVip In Vivo Solid-Phase Microextraction with Palladium-Doped Covalent Organic Framework-Coated Fiber for Enhanced Nicotine-Associated Metabolite Detection in Rat Brain Regions ????Anal Chem http://www.kidney.de/pget.php?&tw=1&pmid=41353665 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41353665 #FOAvip English Wikipedia <ref>{{Cite pmid|41353665}}</ref> In Vivo Solid-Phase Microextraction with Palladium-Doped Covalent Organic Framework-Coated Fiber for Enhanced Nicotine-Associated Metabolite Detection in Rat Brain Regions #MMPMID41353665 Zhang W; Lin C; Wu C; Mao J; Fan W; Wang D; Zhang Q; Chai G; Zhang S; Xie J Anal Chem 2025[Dec]; ? (?): ? PMID41353665show ga Nicotine's neuroactive properties and influence on brain metabolism are not widely explored, particularly in spatially resolved contexts. This technical note presents an in vivo solid-phase microextraction method coupled with UHPLC-TOF/MS to investigate the temporo-spatial distribution of nicotine-associated metabolites in rat brain regions. The coating material, a Palladium-doped covalent organic framework (I-TFBPT-COF@Pd), exhibited a large surface area, suitable pore diameter, and good biocompatibility. The metabolite distribution pattern spectra demonstrated SPME's superior adsorption performance, as evidenced by a broader and more uniform distribution of metabolites. Principal component analysis and orthogonal partial least-squares discriminant analysis indicated that nicotine exposure induced a profound alteration in the metabolite composition of the experimental samples. In addition, 46 differential metabolites and 7 key pathways in the hippocampus and striatum were identified, which revealed the range of nicotine's influence on various biochemical processes, including neurotransmitter synthesis, energy metabolism, and inflammation regulation. This method provides an effective way to study the potential neural effects of nicotine in the brain, surpassing traditional sampling techniques, and it has broad application prospects in biomedicine. ?In Vivo Solid-Phase Microextraction with Palladium-Doped Covalent Orga(epmc).pdf DeepDyve Pubget Overpricing