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10.1038/s41419-025-08276-7 http://scihub22266oqcxt.onion/10.1038/s41419-025-08276-7 41353440!?!41353440 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41353440&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cell+Death+Dis 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41353440|t=2025. CSNK1D inhibition suppresses head and neck squamous cell carcinoma progression through SHH and PTCH1 pathway |pdf=|usr=}}{{41353440}} gab.com Text CSNK1D inhibition suppresses head and neck squamous cell carcinoma progression through SHH and PTCH1 pathway JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=41353440 #FOAvip Casein kinase 1delta (CK1delta, encoded by casein kinase 1 delta) (CSNK1D) is a serine/threonine protein kinase closely associated with cancer development. However, the biological functions of CSNK1D in head and neck squamous cell carcinoma (HNSCC) remain unclear. This study identifies CSNK1D as a previously unrecognized yet crucial regulator in the progression of HNSCC. CSNK1D expression levels were upregulated in tumor tissues and the up-regulation was positively correlated with poor survival in patients with HNSCC. Moreover, CSNK1D selectively bound SHH and PTCH1, and regulated the stability of the CSNK1D-SHH-PTCH1 complex to control the GLI1-BCL2 axis, leading to the downstream activation of the hedgehog pathway. SB-203580 could target and inhibit CSNK1D, offering new perspectives for the clinical treatment of HNSCC. Overall, CSNK1D is underscored as a vital oncogenic driver and promising therapeutic target for HNSCC. Twit Text FOAVip CSNK1D inhibition suppresses head and neck squamous cell carcinoma progression through SHH and PTCH1 pathway ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=41353440 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41353440 #FOAvip English Wikipedia <ref>{{Cite pmid|41353440}}</ref> CSNK1D inhibition suppresses head and neck squamous cell carcinoma progression through SHH and PTCH1 pathway #MMPMID41353440 Yang L; Li X; Zhu Y; Zhang Y; Liu Z; Lin C; Jiang C; Su YX; Ji T; Wang Y; Gao J; Ye J Cell Death Dis 2025[Dec]; ? (?): ? PMID41353440show ga Casein kinase 1delta (CK1delta, encoded by casein kinase 1 delta) (CSNK1D) is a serine/threonine protein kinase closely associated with cancer development. However, the biological functions of CSNK1D in head and neck squamous cell carcinoma (HNSCC) remain unclear. This study identifies CSNK1D as a previously unrecognized yet crucial regulator in the progression of HNSCC. CSNK1D expression levels were upregulated in tumor tissues and the up-regulation was positively correlated with poor survival in patients with HNSCC. Moreover, CSNK1D selectively bound SHH and PTCH1, and regulated the stability of the CSNK1D-SHH-PTCH1 complex to control the GLI1-BCL2 axis, leading to the downstream activation of the hedgehog pathway. SB-203580 could target and inhibit CSNK1D, offering new perspectives for the clinical treatment of HNSCC. Overall, CSNK1D is underscored as a vital oncogenic driver and promising therapeutic target for HNSCC. ?CSNK1D inhibition suppresses head and neck squamous cell carcinoma pro(epmc).pdf DeepDyve Pubget Overpricing