Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/jcla.70144 http://scihub22266oqcxt.onion/10.1002/jcla.70144 41351290!?!41351290 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41351290&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Clin+Lab+Anal 2025 ; ? (?): e70144 Nephropedia Template TP {{tp|p=41351290|t=2025. Reduced Serum Soluble L-Selectin Levels but Not PCSK9 May Be Associated With Generalized Anxiety Disorder: A Case-Control Study |pdf=|usr=}}{{41351290}} gab.com Text Reduced Serum Soluble L-Selectin Levels but Not PCSK9 May Be Associated With Generalized Anxiety Disorder: A Case-Control Study JO: J Clin Lab Anal http://www.kidney.de/pget.php?&tw=1&pmid=41351290 #FOAvip BACKGROUND: Generalized anxiety disorder (GAD) is a complex psychiatric disorder characterized by constant, unconstrained worrying. This investigation aimed to explore the potential role of soluble L-selectin (sL-selectin) and proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathogenesis of GAD. METHODS: The study included 88 patients and 88 healthy controls (HCs) matched with age and sex. A psychiatrist confirmed the GAD diagnosis, assessed symptom severity using the GAD-7 scale, and evaluated controls based on the DSM-5 criteria. Serum levels of sL-selectin and PCSK9 were quantified using commercially available ELISA kits. RESULTS: Serum sL-selectin concentrations were notably lower in GAD patients than HCs (0.51 +/- 0.07 mug/mL vs. 1.52 +/- 0.18 mug/mL). Additionally, there was a significant inverse association between sL-selectin levels and GAD-7 scores (r = -0.359, p = 0.001). This sL-selectin also demonstrated strong predictive ability in the ROC investigation, with an area under the curve (AUC) of 0.718 (p < 0.001), indicating 64.3% sensitivity and 76.5% specificity at a threshold of 0.60 mug/mL. In contrast, no notable difference was observed for serum PCSK9 levels between GAD patients and HCs. CONCLUSION: This study provides a better understanding of the relationship between inflammatory cytokines and GAD pathogenesis. The results indicate that sL-selectin, rather than PCSK9, may be associated with the pathophysiology of GAD. Still, more advanced investigations with greater sample sizes and extensive studies are essential to verify the probable diagnostic utility of serum sL-selectin levels. Twit Text FOAVip Reduced Serum Soluble L-Selectin Levels but Not PCSK9 May Be Associated With Generalized Anxiety Disorder: A Case-Control Study ????J Clin Lab Anal http://www.kidney.de/pget.php?&tw=1&pmid=41351290 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41351290 #FOAvip English Wikipedia <ref>{{Cite pmid|41351290}}</ref> Reduced Serum Soluble L-Selectin Levels but Not PCSK9 May Be Associated With Generalized Anxiety Disorder: A Case-Control Study #MMPMID41351290 Munny FA; Pranto AH; Paul S; Haque MA; Sharmin R; Sultana S; Hossain MA; Islam MR J Clin Lab Anal 2025[Dec]; ? (?): e70144 PMID41351290show ga BACKGROUND: Generalized anxiety disorder (GAD) is a complex psychiatric disorder characterized by constant, unconstrained worrying. This investigation aimed to explore the potential role of soluble L-selectin (sL-selectin) and proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathogenesis of GAD. METHODS: The study included 88 patients and 88 healthy controls (HCs) matched with age and sex. A psychiatrist confirmed the GAD diagnosis, assessed symptom severity using the GAD-7 scale, and evaluated controls based on the DSM-5 criteria. Serum levels of sL-selectin and PCSK9 were quantified using commercially available ELISA kits. RESULTS: Serum sL-selectin concentrations were notably lower in GAD patients than HCs (0.51 +/- 0.07 mug/mL vs. 1.52 +/- 0.18 mug/mL). Additionally, there was a significant inverse association between sL-selectin levels and GAD-7 scores (r = -0.359, p = 0.001). This sL-selectin also demonstrated strong predictive ability in the ROC investigation, with an area under the curve (AUC) of 0.718 (p < 0.001), indicating 64.3% sensitivity and 76.5% specificity at a threshold of 0.60 mug/mL. In contrast, no notable difference was observed for serum PCSK9 levels between GAD patients and HCs. CONCLUSION: This study provides a better understanding of the relationship between inflammatory cytokines and GAD pathogenesis. The results indicate that sL-selectin, rather than PCSK9, may be associated with the pathophysiology of GAD. Still, more advanced investigations with greater sample sizes and extensive studies are essential to verify the probable diagnostic utility of serum sL-selectin levels. ?Reduced Serum Soluble L-Selectin Levels but Not PCSK9 May Be Associate(epmc).pdf DeepDyve Pubget Overpricing