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Motor Intention Quantization for Patients With Disorders of Consciousness by Multimodal BCI Combining Electroencephalography and Functional Near-Infrared Spectroscopy #MMPMID41351188
Wang N; Chai X; Song J; He Y; He Q; Zhang T; Liu D; Li J; Cao T; Zhu S; Jia Y; Si J; Ma W; Yang Y; Zhao J
CNS Neurosci Ther 2025[Dec]; 31 (12): e70679 PMID41351188show ga
OBJECTIVE: The current application of single-modality electroencephalography (EEG) or functional near-infrared spectroscopy (fNIRS) to assess consciousness levels in patients with disorders of consciousness (DoC) has garnered significant attention. However, the diagnostic accuracy of unimodal approaches remains suboptimal. Therefore, this study aims to apply the multimodal fusion technology of EEG and fNIRS to the clinical diagnosis of DoC patients. METHODS: Eleven patients with DoC (six with a minimally conscious state [MCS] and five with a vegetative state [VS]) were enrolled. The motor intention-based brain-computer interface (MI-BCI) paradigm was adopted. EEG and fNIRS were recorded simultaneously. The synchronous states of EEG and fNIRS were analyzed, including time-frequency analysis, event-related desynchronization (ERD), and changes in oxy-hemoglobin (HbO)/de-oxygenated (HbR)/total hemoglobin (HbT) content. A multimodal method combining EEG and fNIRS was used to classify DoC patients. RESULTS: The machine-learning results of the MI-BCI model showed that the EEG-fNIRS multimodal approach was superior to single-modality techniques in the diagnosis of healthy controls (HC), MCS, and VS. The multimodal model achieved a mean AUC of 0.69 +/- 0.10, significantly outperforming both unimodal EEG (0.43 +/- 0.19; p < 0.01) and standalone fNIRS (0.63 +/- 0.10; p < 0.05). The EEG_ERD index of left-handed MI-BCI significantly differentiated the MCS and VS groups. Meanwhile, for the classification tasks of HC, MCS, and VS, the importance ranking of the indicators was as follows: fNIRS_ACC, EEG_ACC, fNIRS_slope, fNIRS_centroid, EEG_ERD, fNIRS_integral, and fNIRS_mean. CONCLUSION: The integration of multimodal MI-BCI paradigms demonstrates clinical potential in evaluating consciousness levels, while the synergistic combination of neurophysiological and hemodynamic biomarkers provides a robust framework for enhancing the precision of bedside diagnostic protocols. TRIAL REGISTRATION: Clinical Trial Registry: ChiCTR2400085830.
CNS+Neurosci+Ther 2025 ; 31 (12): e70679
