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10.1021/acs.analchem.5c04443

http://scihub22266oqcxt.onion/10.1021/acs.analchem.5c04443
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41347451!?!41347451

suck abstract from ncbi

pmid41347451      Anal+Chem 2025 ; ? (?): ?
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  • Aptamer-Linked Terahertz Meta-Sensor for Sensitive and Specific Detection of Carcinoembryonic Antigen #MMPMID41347451
  • Tian Z; Yuan Q; Zhao R; Niu Q; Murtaza G; Yang Y
  • Anal Chem 2025[Dec]; ? (?): ? PMID41347451show ga
  • An aptamer-linked terahertz metamaterial sensor (ALT-Meta sensor) is presented for the sensitive detection of Carcinoembryonic Antigen (CEA), a biomarker of cancer in humans. The ALT-Meta sensor incorporates two symmetric split-ring resonators within a single unit cell, which boasts an exceptionally high quality (Q) factor of 20.4. Leveraging the silico SELEX method, we obtained a highly specific CEA-targeting aptamer (Seq >571) that significantly amplifies the sensor's sensitivity while maintaining its remarkable specificity. Experimental results demonstrate that the ALT-Meta sensor exhibits a robust response to CEA concentrations ranging from 0.1 to 100 ng/mL, with a detection limit as low as 13 pg/mL, which is an order of magnitude lower than that of traditional antibody-based sensors. Its simplicity, stability, and cost-effectiveness make it a highly efficient platform for accurate CEA detection, advancing early cancer diagnostics.
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