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10.1039/d5ob01509j

http://scihub22266oqcxt.onion/10.1039/d5ob01509j
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41347421!?!41347421

suck abstract from ncbi

pmid41347421      Org+Biomol+Chem 2025 ; ? (?): ?
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  • A nickel-catalyzed isocyanide insertion reaction with aromatic amines: direct access to open-chain guanidines #MMPMID41347421
  • Zheng Z; Ma H; Jin H; Zhou B; Hu Y
  • Org Biomol Chem 2025[Dec]; ? (?): ? PMID41347421show ga
  • Herein, a nickel-catalyzed isocyanide insertion reaction with aromatic amines under open-air conditions is disclosed. A number of open-chain guanidines are successfully synthesized in moderate to good yields and their structures are confirmed by X-ray diffraction analysis. This reaction features mild reaction conditions, readily available starting materials and easy operation. Halogen atoms including F, Cl, Br and I are all compatible with the reaction. Mechanistic studies reveal that oxygen in the air might act as an oxidant.
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