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10.1038/s41598-025-27328-8 http://scihub22266oqcxt.onion/10.1038/s41598-025-27328-8 41345475!?!41345475 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41345475&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Sci+Rep 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41345475|t=2025. Dysglycaemia and the interaction of chronic and acute glycaemia with mortality post cardiac surgery |pdf=|usr=}}{{41345475}} gab.com Text Dysglycaemia and the interaction of chronic and acute glycaemia with mortality post cardiac surgery JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=41345475 #FOAvip Hyperglycaemia, glycaemic variability and hypoglycaemia, are associated with adverse outcomes in the critically ill. In the cardiac surgical population, the relationship between these metrics and outcomes is poorly defined. We aimed to characterise the relationships between acute dysglycaemia, chronic hyperglycaemia and outcomes in a cardiac surgical population. Using the Medical Information Mart for Intensive Care IV v1.0 (MIMIC IV-v1.0) database, we compiled a dataset of cardiac surgical patients from 2008 to 2019. Multivariable analysis was performed to assess the independent effect of glucose metrics on mortality while controlling for confounders. Prior hyperglycaemia was assessed by measurement of glycated haemoglobin (HbA(1c)) pre-operatively. Of the 9132 patients included in the analysis, 27% had known diabetes and the prevalence of unrecognised diabetes was 11%. The mean, cumulative dose of hyperglycaemia and coefficient of variation of blood glucose level all increased significantly (P<0.001) with greater pre-operative HbA(1c). Acute hyperglycaemia was strongly associated with mortality (OR 5.88, 95% CI, 3.03 to 10.6), although this effect was diminished by exposure to chronic hyperglycaemia (HbA(1c) >/=6.5%). Hypoglycaemia was strongly associated with mortality irrespective of premorbid glycaemic control. The findings indicate that chronic pre-operative hyperglycaemia attenuates the association between acute hyperglycaemia, glycaemic variability and mortality in the cardiac surgical population, but does not modify the mortality risk associated with hypoglycaemia. Twit Text FOAVip Dysglycaemia and the interaction of chronic and acute glycaemia with mortality post cardiac surgery ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=41345475 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41345475 #FOAvip English Wikipedia <ref>{{Cite pmid|41345475}}</ref> Dysglycaemia and the interaction of chronic and acute glycaemia with mortality post cardiac surgery #MMPMID41345475 Shi J; Plummer M; Perry L; Karamesinis A; Hinton JV; Fletcher CM; Penny-Dimri JC; Ramson DM; Liu Z; Segal R; Smith JA; Horowitz M; Serpa-Neto A; Nadkarni A Sci Rep 2025[Dec]; ? (?): ? PMID41345475show ga Hyperglycaemia, glycaemic variability and hypoglycaemia, are associated with adverse outcomes in the critically ill. In the cardiac surgical population, the relationship between these metrics and outcomes is poorly defined. We aimed to characterise the relationships between acute dysglycaemia, chronic hyperglycaemia and outcomes in a cardiac surgical population. Using the Medical Information Mart for Intensive Care IV v1.0 (MIMIC IV-v1.0) database, we compiled a dataset of cardiac surgical patients from 2008 to 2019. Multivariable analysis was performed to assess the independent effect of glucose metrics on mortality while controlling for confounders. Prior hyperglycaemia was assessed by measurement of glycated haemoglobin (HbA(1c)) pre-operatively. Of the 9132 patients included in the analysis, 27% had known diabetes and the prevalence of unrecognised diabetes was 11%. The mean, cumulative dose of hyperglycaemia and coefficient of variation of blood glucose level all increased significantly (P<0.001) with greater pre-operative HbA(1c). Acute hyperglycaemia was strongly associated with mortality (OR 5.88, 95% CI, 3.03 to 10.6), although this effect was diminished by exposure to chronic hyperglycaemia (HbA(1c) >/=6.5%). Hypoglycaemia was strongly associated with mortality irrespective of premorbid glycaemic control. The findings indicate that chronic pre-operative hyperglycaemia attenuates the association between acute hyperglycaemia, glycaemic variability and mortality in the cardiac surgical population, but does not modify the mortality risk associated with hypoglycaemia. ?Dysglycaemia and the interaction of chronic and acute glycaemia with m(epmc).pdf DeepDyve Pubget Overpricing