Novel decanoic acid derivatives and 3-farnesyl-p-hydroxybenzoic acid derivatives from the marine fungus Aureobasidium pullulans 8438 #MMPMID41343713
Liu J; Bujianati Y; Peng H; Bian H; Peng Y; Lu R; Huang J; Li K; Ding B; Huang H; Tao Y
Nat Prod Res 2025[Dec]; ? (?): 1-7 PMID41343713show ga
Eleven compounds were isolated from the secondary metabolites of the marine fungus Aureobasidium pullulans 8438, including three novel compounds, 9-hydroxy-massoia lactone (1), Ethyl p-hydroxybenzoate (3 R,5R)-3,5-dihydroxydecanoate (2), and (R)-9,10-dihydroxypropyl 4-hydroxy-5-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien -1-yl) benzoate (3), along with 8 known compounds (4-11). Compounds 1, 2 and 4-9 are decanoic acid derivatives, while both compounds 3 and 11 are 3-farnesyl-p-hydroxybenzoic acid derivatives. The planar structures of the new compounds were determined using high-resolution mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR) data. Their absolute configurations were established through the Snatzke method, quantum chemical calculations (including computational NMR and ECD), and DP4+ analysis. All isolated compounds were evaluated for their cytotoxic effects against human non-small cell lung cancer cells A549 and human cervical cancer cells HeLa.
Nat+Prod+Res 2025 ; ? (?): 1-7
