The use of brain-specific biomarkers in urine for prediction of neurological outcome and extent of tissue damage following stroke #MMPMID41339674
Lieschke F; Marggrander DT; Rauch M; Schaefer JH; Bohmann FO; Foerch C; Grefkes C; Kohlhase K
Sci Rep 2025[Dec]; 15 (1): 43089 PMID41339674show ga
Serum biomarkers of neuronal and glial damage gained significant attention in recent years for their diagnostic and prognostic value in acute stroke. In this study, we explored the potential of spot urine testing as a practical, non-invasive alternative. Using ultrasensitive single-molecule arrays, we assessed levels of glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and total tau (t-tau) in urine and blood samples from hospitalized patients with acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) within 96 h after symptom onset. The results were correlated with mortality rates, tissue damage extent and modified Rankin Scale (mRS) scores at discharge and after three months. Significant variables were included into an multivariate regression model with confounder correction (NIHSS at admission, age at onset and serum creatinine). As a result, absolute concentrations of urine GFAP, NfL and t-tau were significantly higher in patients with in-hospital death or death at 3 months follow-up compared to patients reaching a mRS
Sci+Rep 2025 ; 15 (1): 43089
