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10.1038/s41467-025-66619-6 http://scihub22266oqcxt.onion/10.1038/s41467-025-66619-6 41339624!?!41339624 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41339624&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Nat+Commun 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41339624|t=2025. Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity |pdf=|usr=}}{{41339624}} gab.com Text Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=41339624 #FOAvip Emerging studies reveal that gut microbes can conjugate diverse amino acids to bile acids, known as microbially conjugated bile acids. However, their regulation and health effects remain unclear. Here, we analyzed early-life microbially conjugated bile acid patterns and their link to islet autoimmunity. We quantified 110 microbial bile acids in 303 stool samples collected longitudinally (3-36 months) from children who developed one or more islet autoantibodies and controls who remained autoantibody-negative. We identified distinct age-dependent trajectories of these bile acid amidates and correlated them with gut microbiome composition. We found that altered levels of ursodeoxycholic and deoxycholic acid conjugates were linked to islet autoimmunity as well as modulated monocyte activation in response to immunostimulatory lipopolysaccharide and Th17/Treg cell balance. These findings suggest that microbially conjugated bile acids influence immune development and type 1 diabetes risk. Twit Text FOAVip Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=41339624 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41339624 #FOAvip English Wikipedia <ref>{{Cite pmid|41339624}}</ref> Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity #MMPMID41339624 Lamichhane S; Dickens AM; Buchacher T; Lou T; Charron-Lamoureux V; Kattelus R; Karmacharya P; da Silva LP; Krakstrom M; Rasool O; Sen P; Walker C; Patan A; Gentry EC; Zuffa S; Arzoomand A; Lakshmikanth T; Mikes J; Mebrahtu A; Vatanen T; Raffatellu M; Zengler K; Hyotylainen T; Xavier RJ; Brodin P; Lahesmaa R; Dorrestein PC; Knip M; Oresic M Nat Commun 2025[Dec]; ? (?): ? PMID41339624show ga Emerging studies reveal that gut microbes can conjugate diverse amino acids to bile acids, known as microbially conjugated bile acids. However, their regulation and health effects remain unclear. Here, we analyzed early-life microbially conjugated bile acid patterns and their link to islet autoimmunity. We quantified 110 microbial bile acids in 303 stool samples collected longitudinally (3-36 months) from children who developed one or more islet autoantibodies and controls who remained autoantibody-negative. We identified distinct age-dependent trajectories of these bile acid amidates and correlated them with gut microbiome composition. We found that altered levels of ursodeoxycholic and deoxycholic acid conjugates were linked to islet autoimmunity as well as modulated monocyte activation in response to immunostimulatory lipopolysaccharide and Th17/Treg cell balance. These findings suggest that microbially conjugated bile acids influence immune development and type 1 diabetes risk. ?Microbiome-derived bile acid signatures in early life and their associ(epmc).pdf DeepDyve Pubget Overpricing