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10.1002/cmdc.202500503 http://scihub22266oqcxt.onion/10.1002/cmdc.202500503 41319341!?!41319341 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41319341&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       ChemMedChem 2025 ; ? (?): e202500503 Nephropedia Template TP {{tp|p=41319341|t=2025. Development of New Benzo b Thiophene-2-Carboxamide Derivatives as Advanced Glycation End-Products Receptor (RAGE) Antagonists |pdf=|usr=}}{{41319341}} gab.com Text Development of New Benzo b Thiophene-2-Carboxamide Derivatives as Advanced Glycation End-Products Receptor (RAGE) Antagonists JO: ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=41319341 #FOAvip The activation of the receptor for advanced glycation end-products (RAGE) induces a chronic, low-noise inflammation responsible for the aging process, known as inflammaging. Associated with numerous pathologies such as Alzheimer's, insulin-resistant diabetes, cardiovascular diseases, and certain cancers, RAGE has become an interesting therapeutic target in the context of aging well. To this end, we identified new benzo[b]thiophene-2-carboxamide derivatives as potential RAGE ligands. Herein, we developed an alternative approach to easily synthesize benzo[b]thiophene-2-carboxamide analogs from 5-arylidene-2,4-thiazolidinedione intermediates based on the Ullmann-Goldberg coupling conditions. In light of LCMS, NMR, X-ray, and DFT studies, a mechanism for this reaction was proposed. This novel strategy enabled us to synthesize analogs whose best molecule 3t', with an IC(50) of 13.2 microM, shows similar interactions with RAGE as the reference molecule Azeliragon (13.0 microM). Twit Text FOAVip Development of New Benzo b Thiophene-2-Carboxamide Derivatives as Advanced Glycation End-Products Receptor (RAGE) Antagonists ????ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=41319341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41319341 #FOAvip English Wikipedia <ref>{{Cite pmid|41319341}}</ref> Development of New Benzo b Thiophene-2-Carboxamide Derivatives as Advanced Glycation End-Products Receptor (RAGE) Antagonists #MMPMID41319341 Bonin L; Hedouin M; Furman C; Not O; Lancel S; Bensalah M; Coadou G; Boulanger E; Shova S; Oulyadi H; Ghinet A ChemMedChem 2025[Nov]; ? (?): e202500503 PMID41319341show ga The activation of the receptor for advanced glycation end-products (RAGE) induces a chronic, low-noise inflammation responsible for the aging process, known as inflammaging. Associated with numerous pathologies such as Alzheimer's, insulin-resistant diabetes, cardiovascular diseases, and certain cancers, RAGE has become an interesting therapeutic target in the context of aging well. To this end, we identified new benzo[b]thiophene-2-carboxamide derivatives as potential RAGE ligands. Herein, we developed an alternative approach to easily synthesize benzo[b]thiophene-2-carboxamide analogs from 5-arylidene-2,4-thiazolidinedione intermediates based on the Ullmann-Goldberg coupling conditions. In light of LCMS, NMR, X-ray, and DFT studies, a mechanism for this reaction was proposed. This novel strategy enabled us to synthesize analogs whose best molecule 3t', with an IC(50) of 13.2 microM, shows similar interactions with RAGE as the reference molecule Azeliragon (13.0 microM). ?Development of New Benzo b Thiophene-2-Carboxamide Derivatives as Adva(epmc).pdf DeepDyve Pubget Overpricing