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10.1111/exd.70181 http://scihub22266oqcxt.onion/10.1111/exd.70181 41319262!?!41319262 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41319262&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Exp+Dermatol 2025 ; 34 (12): e70181 Nephropedia Template TP {{tp|p=41319262|t=2025. Comparative Transcriptomics Reveals a Dual Role of the Epidermal Differentiation Complex in the Skin and the Oesophagus |pdf=|usr=}}{{41319262}} gab.com Text Comparative Transcriptomics Reveals a Dual Role of the Epidermal Differentiation Complex in the Skin and the Oesophagus JO: Exp Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=41319262 #FOAvip The epidermal differentiation complex (EDC) is a cluster of genes implicated in the control of the skin barrier. However, some EDC genes are also expressed at high levels in the human oesophagus. To determine whether the expression of EDC genes in the oesophagus is evolutionarily conserved, we performed comparative transcriptomic analyses of the skin and the oesophagus in humans, mice and chickens. Transcriptomes from public databases and newly generated RNA-sequencing data of the chicken oesophagus were compared. We found that the EDC of both mammals and birds contains genes that are predominantly expressed in the skin and others that are predominantly expressed in the oesophagus. Cornulin is strongly enriched in the oesophagus of humans and chickens. Similar to small proline-rich proteins in the human and murine oesophagus, an EDC protein rich in proline is predominantly expressed in the chicken oesophagus. Further oesophagus-enriched EDC genes are specific to phylogenetic lineages. This study indicates that the EDC plays evolutionarily ancient roles not only in the epidermis of the skin but also in the epithelium of the oesophagus. In line with the dual function of the EDC, dysregulation of EDC gene expression is associated with pathological changes in both stratified epithelia. Twit Text FOAVip Comparative Transcriptomics Reveals a Dual Role of the Epidermal Differentiation Complex in the Skin and the Oesophagus ????Exp Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=41319262 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41319262 #FOAvip English Wikipedia <ref>{{Cite pmid|41319262}}</ref> Comparative Transcriptomics Reveals a Dual Role of the Epidermal Differentiation Complex in the Skin and the Oesophagus #MMPMID41319262 Sachslehner AP; Lachner J; Mlitz V; Golabi B; Hess C; Sipos W; Eckhart L Exp Dermatol 2025[Dec]; 34 (12): e70181 PMID41319262show ga The epidermal differentiation complex (EDC) is a cluster of genes implicated in the control of the skin barrier. However, some EDC genes are also expressed at high levels in the human oesophagus. To determine whether the expression of EDC genes in the oesophagus is evolutionarily conserved, we performed comparative transcriptomic analyses of the skin and the oesophagus in humans, mice and chickens. Transcriptomes from public databases and newly generated RNA-sequencing data of the chicken oesophagus were compared. We found that the EDC of both mammals and birds contains genes that are predominantly expressed in the skin and others that are predominantly expressed in the oesophagus. Cornulin is strongly enriched in the oesophagus of humans and chickens. Similar to small proline-rich proteins in the human and murine oesophagus, an EDC protein rich in proline is predominantly expressed in the chicken oesophagus. Further oesophagus-enriched EDC genes are specific to phylogenetic lineages. This study indicates that the EDC plays evolutionarily ancient roles not only in the epidermis of the skin but also in the epithelium of the oesophagus. In line with the dual function of the EDC, dysregulation of EDC gene expression is associated with pathological changes in both stratified epithelia. |*Epidermis/metabolism[MESH] |*Esophagus/metabolism[MESH] |*Skin/metabolism[MESH] |*Transcriptome[MESH] |Animals[MESH] |Cell Differentiation/genetics[MESH] |Chickens[MESH] |Cornified Envelope Proline-Rich Proteins/genetics/metabolism[MESH] |Gene Expression Profiling[MESH] |Humans[MESH]Comparative Transcriptomics Reveals a Dual Role of the Epidermal Diffe(epmc).pdf DeepDyve Pubget Overpricing