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10.1021/acs.jmedchem.5c02157 http://scihub22266oqcxt.onion/10.1021/acs.jmedchem.5c02157 41319212!?!41319212       J+Med+Chem 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41319212|t=2025. Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived Inhibitors of the Proprotein Convertase Furin |pdf=|usr=}}{{41319212}} gab.com Text Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived Inhibitors of the Proprotein Convertase Furin JO: J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=41319212 #FOAvip The proprotein convertase (PC) furin emerged as promising drug target for the treatment of numerous infectious diseases, cancer and cystic fibrosis. A recently described nonpeptidic lead structure served as template to develop a new series of PC inhibitors containing a dichlorobiphenyl-derived core segment decorated with a left and right inhibitor arm. The compounds were tested for their inhibitory potency against furin and the structurally related PC7. The most potent compounds inhibited furin with K(i) values <5 nM, whereas most of them were significantly weaker inhibitors of PC7. Only for one compound, a significant potency with a K(i) value of 7.3 nM against PC7 was found. Furthermore, crystal structures of six inhibitors in complex with furin were determined. Selected inhibitors were additionally tested for their antiviral potency against the furin-dependent H7N7 influenza A strain SC35M; a significant antiviral potency was found for compound 9. Twit Text FOAVip Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived Inhibitors of the Proprotein Convertase Furin ????J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=41319212 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41319212 #FOAvip English Wikipedia <ref>{{Cite pmid|41319212}}</ref> Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived Inhibitors of the Proprotein Convertase Furin #MMPMID41319212 Lange RW; Boller C; Loresch M; Bloch K; Bottcher-Friebertshauser E; Brandstetter H; Dahms SO; Steinmetzer T J Med Chem 2025[Nov]; ? (?): ? PMID41319212show ga The proprotein convertase (PC) furin emerged as promising drug target for the treatment of numerous infectious diseases, cancer and cystic fibrosis. A recently described nonpeptidic lead structure served as template to develop a new series of PC inhibitors containing a dichlorobiphenyl-derived core segment decorated with a left and right inhibitor arm. The compounds were tested for their inhibitory potency against furin and the structurally related PC7. The most potent compounds inhibited furin with K(i) values <5 nM, whereas most of them were significantly weaker inhibitors of PC7. Only for one compound, a significant potency with a K(i) value of 7.3 nM against PC7 was found. Furthermore, crystal structures of six inhibitors in complex with furin were determined. Selected inhibitors were additionally tested for their antiviral potency against the furin-dependent H7N7 influenza A strain SC35M; a significant antiviral potency was found for compound 9. ?Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived In(epmc).pdf DeepDyve Pubget Overpricing