A Novel Approach to the Treatment of Familial Expansile Osteolysis: A Rare Genetic Bone Pathology: A Case Report #MMPMID41264685
Lennon S; Allen P; Johnson L
JBJS Case Connect 2025[Oct]; 15 (4): ? PMID41264685show ga
CASE: Familial expansile osteolysis (FEO) is a rare inherited autosomal dominant condition causing the development of painful lytic bone lesions. We present the case of a 54-year-old man with FEO who was treated with denosumab. The patient's progress was monitored with radiographs, magnetic resonance imaging, bone turnover markers, pain, and functional scores. CONCLUSION: The use of denosumab for FEO displays improvement in radiological appearances of the affected bone, increased quality of life and may prevent the development of further lesions. It is a safe treatment modality for patients with FEO that allows for limb salvage surgery rather than amputation.
|*Bone Density Conservation Agents/therapeutic use[MESH]