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e25.00353

http://scihub22266oqcxt.onion/e25.00353
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41264685!?!41264685

suck abstract from ncbi

pmid41264685      JBJS+Case+Connect 2025 ; 15 (4): ?
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  • A Novel Approach to the Treatment of Familial Expansile Osteolysis: A Rare Genetic Bone Pathology: A Case Report #MMPMID41264685
  • Lennon S; Allen P; Johnson L
  • JBJS Case Connect 2025[Oct]; 15 (4): ? PMID41264685show ga
  • CASE: Familial expansile osteolysis (FEO) is a rare inherited autosomal dominant condition causing the development of painful lytic bone lesions. We present the case of a 54-year-old man with FEO who was treated with denosumab. The patient's progress was monitored with radiographs, magnetic resonance imaging, bone turnover markers, pain, and functional scores. CONCLUSION: The use of denosumab for FEO displays improvement in radiological appearances of the affected bone, increased quality of life and may prevent the development of further lesions. It is a safe treatment modality for patients with FEO that allows for limb salvage surgery rather than amputation.
  • |*Bone Density Conservation Agents/therapeutic use[MESH]
  • |*Denosumab/therapeutic use[MESH]
  • |*Osteolysis/drug therapy/diagnostic imaging/genetics[MESH]
  • |Humans[MESH]
  • |Male[MESH]


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