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10.1038/s44321-025-00321-4 http://scihub22266oqcxt.onion/10.1038/s44321-025-00321-4 41131424!ä!41131424 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41131424.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+Mol+Med 2025 ; ä (ä): ä Nephropedia Template TP {{tp|p=41131424|t=2025. CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay |pdf=|usr=}}{{41131424}} gab.com Text CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=41131424 #FOAvip CARD14 is an intracellular NF-kappaB signaling mediator in the skin, and rare CARD14 variants have been associated with psoriasis and atopic dermatitis. CARD14 is also expressed in intestinal epithelial cells (IEC). However, its function in the intestine remains unknown. We demonstrate here that transgenic mice expressing the psoriasis-associated gain-of-function human CARD14(E138A) mutant specifically in IEC show mild intestinal inflammation, without epithelial damage. Moreover, CARD14(E138A)(IEC) mice show a drastic reduction in intestinal motility, often associated with rectal prolapse. Enteric neuronal survival and functionality are unaffected in CARD14(E138A)(IEC) mice. Transcriptome analysis of IEC from CARD14(E138A)(IEC) mice reveals decreased expression of antimicrobial peptides by Paneth cells, accompanied by microbial dysbiosis and increased susceptibility to enteric bacterial infection. Our findings suggest that gain-of-function CARD14 mutations may not only predispose patients to psoriasis but also mild intestinal inflammation, reduced intestinal motility, and increased sensitivity to intestinal infection. CARD14(E138A)(IEC) mice are also a valuable tool for further investigation of IEC-intrinsic molecular processes involved in intestinal inflammation and motility disorders. Twit Text FOAVip CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=41131424 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41131424 #FOAvip English Wikipedia <ref>{{Cite pmid|41131424}}</ref> CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay #MMPMID41131424 Aidarova A; Carels M; Haegman M; Driege Y; Timmermans S; Van Damme E; Aguilera-Lizarraga J; Viola MF; de Cassia Collaco R; Manils J; Ley SC; Bosmans F; Van de Wiele T; Boeckxstaens G; Libert C; Beyaert R; Afonina IS EMBO Mol Med 2025[Oct]; ä (ä): ä PMID41131424show ga CARD14 is an intracellular NF-kappaB signaling mediator in the skin, and rare CARD14 variants have been associated with psoriasis and atopic dermatitis. CARD14 is also expressed in intestinal epithelial cells (IEC). However, its function in the intestine remains unknown. We demonstrate here that transgenic mice expressing the psoriasis-associated gain-of-function human CARD14(E138A) mutant specifically in IEC show mild intestinal inflammation, without epithelial damage. Moreover, CARD14(E138A)(IEC) mice show a drastic reduction in intestinal motility, often associated with rectal prolapse. Enteric neuronal survival and functionality are unaffected in CARD14(E138A)(IEC) mice. Transcriptome analysis of IEC from CARD14(E138A)(IEC) mice reveals decreased expression of antimicrobial peptides by Paneth cells, accompanied by microbial dysbiosis and increased susceptibility to enteric bacterial infection. Our findings suggest that gain-of-function CARD14 mutations may not only predispose patients to psoriasis but also mild intestinal inflammation, reduced intestinal motility, and increased sensitivity to intestinal infection. CARD14(E138A)(IEC) mice are also a valuable tool for further investigation of IEC-intrinsic molecular processes involved in intestinal inflammation and motility disorders. äCARD14 signaling in intestinal epithelial cells induces intestinal inf(epmc).pdf DeepDyve Pubget Overpricing