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10.1111/nmo.70177 http://scihub22266oqcxt.onion/10.1111/nmo.70177 41108548!ä!41108548 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41108548&cmd=llinks): Failed to open stream: HTTP request failed! 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Efficacy of Dupilumab for Induction and Maintenance of Remission in Patients With Eosinophilic Gastritis, Enteritis, and Colitis With Concomitant Eosinophilic Esophagitis |pdf=|usr=}}{{41108548}} gab.com Text Efficacy of Dupilumab for Induction and Maintenance of Remission in Patients With Eosinophilic Gastritis, Enteritis, and Colitis With Concomitant Eosinophilic Esophagitis JO: Neurogastroenterol Motil http://www.kidney.de/pget.php?&tw=1&pmid=41108548 #FOAvip BACKGROUND: Eosinophilic gastrointestinal diseases (EGIDs) are chronic, immune-mediated diseases characterized by pathological infiltration of eosinophils in the gut. EGIDs include eosinophilic esophagitis (EoE), gastritis (EoG), enteritis (EoN), and colitis (EoC). There are no approved drugs for non-EoE EGIDs due to a lack of evidence. AIMS AND METHODS: In this case series, we report the efficacy of dupilumab-prescribed for concomitant EoE-for the induction and maintenance of remission of non-EoE EGIDs. Adult patients (> 18 years) diagnosed with non-EoE EGIDs and concomitant EoE who had been prescribed dupilumab 300 mg weekly were prospectively enrolled. Outcome assessment was performed according to EGID-specific instruments when available (i.e., peak eosinophil count, modified dysphagia questionnaire, Pisa EoE adaptation questionnaire, EoE and EoG endoscopic reference scores). RESULTS: Four patients were included. All were female and their age spanned 21-77 years at diagnosis. Two patients had EoE + EoG (case 1 and 2), one EoE + EoG + EoN (case 3), and one EoE + EoN + EoC (case 4). EoG presented with epigastric pain, while EoN and EoC presented with abdominal pain and diarrhea. Cases 1 and 2 achieved clinical, endoscopic, and histological remission with induction corticosteroid treatment, while case 3 did not, and case 4 developed steroid-related adverse events. When switched to dupilumab 300 mg weekly, cases 1, 2, and 3 achieved histological remission and sustained clinical remission up to 12-18 months from induction. In case 4, dupilumab achieved histologic remission and partial clinical response up to 16 months from induction. CONCLUSION: Dupilumab, prescribed for EoE, may be effective for the management of concomitant non-EoE EGIDs. Twit Text FOAVip Efficacy of Dupilumab for Induction and Maintenance of Remission in Patients With Eosinophilic Gastritis, Enteritis, and Colitis With Concomitant Eosinophilic Esophagitis ????Neurogastroenterol Motil http://www.kidney.de/pget.php?&tw=1&pmid=41108548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41108548 #FOAvip English Wikipedia <ref>{{Cite pmid|41108548}}</ref> Efficacy of Dupilumab for Induction and Maintenance of Remission in Patients With Eosinophilic Gastritis, Enteritis, and Colitis With Concomitant Eosinophilic Esophagitis #MMPMID41108548 Visaggi P; Bini L; Castagnaro E; Cairoli G; Testi F; Mitilini M; Bellini M; Savarino EV; de Bortoli N Neurogastroenterol Motil 2025[Oct]; ä (ä): e70177 PMID41108548show ga BACKGROUND: Eosinophilic gastrointestinal diseases (EGIDs) are chronic, immune-mediated diseases characterized by pathological infiltration of eosinophils in the gut. EGIDs include eosinophilic esophagitis (EoE), gastritis (EoG), enteritis (EoN), and colitis (EoC). There are no approved drugs for non-EoE EGIDs due to a lack of evidence. AIMS AND METHODS: In this case series, we report the efficacy of dupilumab-prescribed for concomitant EoE-for the induction and maintenance of remission of non-EoE EGIDs. Adult patients (> 18 years) diagnosed with non-EoE EGIDs and concomitant EoE who had been prescribed dupilumab 300 mg weekly were prospectively enrolled. Outcome assessment was performed according to EGID-specific instruments when available (i.e., peak eosinophil count, modified dysphagia questionnaire, Pisa EoE adaptation questionnaire, EoE and EoG endoscopic reference scores). RESULTS: Four patients were included. All were female and their age spanned 21-77 years at diagnosis. Two patients had EoE + EoG (case 1 and 2), one EoE + EoG + EoN (case 3), and one EoE + EoN + EoC (case 4). EoG presented with epigastric pain, while EoN and EoC presented with abdominal pain and diarrhea. Cases 1 and 2 achieved clinical, endoscopic, and histological remission with induction corticosteroid treatment, while case 3 did not, and case 4 developed steroid-related adverse events. When switched to dupilumab 300 mg weekly, cases 1, 2, and 3 achieved histological remission and sustained clinical remission up to 12-18 months from induction. In case 4, dupilumab achieved histologic remission and partial clinical response up to 16 months from induction. CONCLUSION: Dupilumab, prescribed for EoE, may be effective for the management of concomitant non-EoE EGIDs. äEfficacy of Dupilumab for Induction and Maintenance of Remission in Pa(epmc).pdf DeepDyve Pubget Overpricing