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10.1016/j.jbc.2025.110685 http://scihub22266oqcxt.onion/10.1016/j.jbc.2025.110685 40914251!ä!40914251 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40914251.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2025 ; ä (ä): 110685 Nephropedia Template TP {{tp|p=40914251|t=2025. Biochemical characterization of a flavodiiron protein from bird parasite Histomonas meleagridis: superoxide as a reaction intermediate |pdf=|usr=}}{{40914251}} gab.com Text Biochemical characterization of a flavodiiron protein from bird parasite Histomonas meleagridis: superoxide as a reaction intermediate JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=40914251 #FOAvip Histomonas meleagridis is a parasitic protozoan which causes histomoniasis (blackhead disease) in a wide range of birds, including domesticated chickens and turkeys, representing a significant health problem in avian veterinary medicine. Despite being classified as an anaerobic parasite, H. meleagridis can survive transient exposure to oxygen while little is known about the mechanisms that allow this organism to cope with exposure to varying oxygen levels. Inspecting the H. meleagridis genome revealed that this organism possesses two flavodiiron proteins (FDPs) belonging to Classes A and F, which are known in other organisms to reduce O(2) to H(2)O. The Class F FDP found in H. meleagridis (HmFDPF) has domain organization previously described for similar proteins and contains a middle rubredoxin-like and C-terminal NADH:rubredoxin oxidoreductase (NROR) domains in addition to an N-terminal FDP core. Here, we present extensive biochemical characterization of this protein to improve understanding of the coordinated activities of multiple redox centers that enable NADH-dependent reduction of O(2) to H(2)O. We found that although superoxide is a HmFDPF reaction intermediate, only a very small amount of H(2)O(2) is released as a byproduct. Moreover, HmFDPF does not possess NADH:H(2)O(2) oxidoreductase activity and the enzyme is prone to quick inactivation by H(2)O(2). In summary, our work expands our understanding of how microaerophilic protozoan parasites maintain their optimal redox state and minimize oxygen presence in their local environment, revealing mechanisms that can be exploited as drug targets against microaerophilic parasites. Twit Text FOAVip Biochemical characterization of a flavodiiron protein from bird parasite Histomonas meleagridis: superoxide as a reaction intermediate ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=40914251 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40914251 #FOAvip English Wikipedia <ref>{{Cite pmid|40914251}}</ref> Biochemical characterization of a flavodiiron protein from bird parasite Histomonas meleagridis: superoxide as a reaction intermediate #MMPMID40914251 Munan S; Yoval-Sanchez B; Yao C; Seravalli J; Abdulaziz EN; Heacock ML; Ramesh A; Galkin A; Cracan V J Biol Chem 2025[Sep]; ä (ä): 110685 PMID40914251show ga Histomonas meleagridis is a parasitic protozoan which causes histomoniasis (blackhead disease) in a wide range of birds, including domesticated chickens and turkeys, representing a significant health problem in avian veterinary medicine. Despite being classified as an anaerobic parasite, H. meleagridis can survive transient exposure to oxygen while little is known about the mechanisms that allow this organism to cope with exposure to varying oxygen levels. Inspecting the H. meleagridis genome revealed that this organism possesses two flavodiiron proteins (FDPs) belonging to Classes A and F, which are known in other organisms to reduce O(2) to H(2)O. The Class F FDP found in H. meleagridis (HmFDPF) has domain organization previously described for similar proteins and contains a middle rubredoxin-like and C-terminal NADH:rubredoxin oxidoreductase (NROR) domains in addition to an N-terminal FDP core. Here, we present extensive biochemical characterization of this protein to improve understanding of the coordinated activities of multiple redox centers that enable NADH-dependent reduction of O(2) to H(2)O. We found that although superoxide is a HmFDPF reaction intermediate, only a very small amount of H(2)O(2) is released as a byproduct. Moreover, HmFDPF does not possess NADH:H(2)O(2) oxidoreductase activity and the enzyme is prone to quick inactivation by H(2)O(2). In summary, our work expands our understanding of how microaerophilic protozoan parasites maintain their optimal redox state and minimize oxygen presence in their local environment, revealing mechanisms that can be exploited as drug targets against microaerophilic parasites. äBiochemical characterization of a flavodiiron protein from bird parasi(epmc).pdf DeepDyve Pubget Overpricing