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10.1016/j.jbc.2025.110684 http://scihub22266oqcxt.onion/10.1016/j.jbc.2025.110684 40914246!ä!40914246 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=40914246&cmd=llinks): Failed to open stream: HTTP request failed! 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Adductome-based identification of lysine mono-methylation as a key post-translational protein modification in autoimmune diseases |pdf=|usr=}}{{40914246}} gab.com Text Adductome-based identification of lysine mono-methylation as a key post-translational protein modification in autoimmune diseases JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=40914246 #FOAvip Posttranslational modifications (PTMs) of proteins are efficient biological mechanisms for expanding the genetic code and for regulating cellular physiology. However, there have been no systematic approaches to profile all the PTMs critical for autoreactive neoantigen production or the etiology and pathology of autoimmune diseases. In the present study, to gain insight into protein PTMs associated with systemic lupus erythematosus (SLE), we applied a mass spectrometry-based method for the comprehensive analysis of modified amino acids ("adductome"). By comprehensively measuring modified lysines and histidines in mouse tissue homogenates from the control and SLE-prone MRL-lpr mice, we observed a significant decrease in lysine mono-methylation as a unique alteration in the PTMs of SLE mice splenocytes. One of the targets for the down-regulation of lysine mono-methylation was identified as histone H3. Down-regulation of histone H3 lysine 4 mono-methylation (H3K4me1) was also observed in the B cells from SLE mice. Inhibition of the H3K4me1 demethylase LSD1 suppressed the differentiation of naive B cells into antibody-secreting cells. In addition, the reduction of H3K4me1 in SLE mice resulted in the down-regulation of PAX5, a transcription factor indispensable for the maturation of B cells, leading to the activation of antibody-secreting cells. The results of this study suggest that dysregulation of histone lysine mono-methylation may play a significant role in the pathophysiology of SLE and therefore may be a target for epigenetic-based lupus treatment. Twit Text FOAVip Adductome-based identification of lysine mono-methylation as a key post-translational protein modification in autoimmune diseases ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=40914246 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40914246 #FOAvip English Wikipedia <ref>{{Cite pmid|40914246}}</ref> Adductome-based identification of lysine mono-methylation as a key post-translational protein modification in autoimmune diseases #MMPMID40914246 Yamaguchi K; Hu YY; Kawajiri K; Itakura M; Nakashima F; Shibata T; Uchida K J Biol Chem 2025[Sep]; ä (ä): 110684 PMID40914246show ga Posttranslational modifications (PTMs) of proteins are efficient biological mechanisms for expanding the genetic code and for regulating cellular physiology. However, there have been no systematic approaches to profile all the PTMs critical for autoreactive neoantigen production or the etiology and pathology of autoimmune diseases. In the present study, to gain insight into protein PTMs associated with systemic lupus erythematosus (SLE), we applied a mass spectrometry-based method for the comprehensive analysis of modified amino acids ("adductome"). By comprehensively measuring modified lysines and histidines in mouse tissue homogenates from the control and SLE-prone MRL-lpr mice, we observed a significant decrease in lysine mono-methylation as a unique alteration in the PTMs of SLE mice splenocytes. One of the targets for the down-regulation of lysine mono-methylation was identified as histone H3. Down-regulation of histone H3 lysine 4 mono-methylation (H3K4me1) was also observed in the B cells from SLE mice. Inhibition of the H3K4me1 demethylase LSD1 suppressed the differentiation of naive B cells into antibody-secreting cells. In addition, the reduction of H3K4me1 in SLE mice resulted in the down-regulation of PAX5, a transcription factor indispensable for the maturation of B cells, leading to the activation of antibody-secreting cells. The results of this study suggest that dysregulation of histone lysine mono-methylation may play a significant role in the pathophysiology of SLE and therefore may be a target for epigenetic-based lupus treatment. äAdductome-based identification of lysine mono-methylation as a key po(epmc).pdf DeepDyve Pubget Overpricing