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10.1016/j.ejps.2025.107230 http://scihub22266oqcxt.onion/10.1016/j.ejps.2025.107230 40784664!ä!40784664 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40784664.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Pharm+Sci 2025 ; 213 (ä): 107230 Nephropedia Template TP {{tp|p=40784664|t=2025. The effect of formulation composition and flow conditions on the robustness of semisolid extrusion 3D printing: a case study on poorly water-soluble itraconazole for oral dosage form production |pdf=|usr=}}{{40784664}} gab.com Text The effect of formulation composition and flow conditions on the robustness of semisolid extrusion 3D printing: a case study on poorly water-soluble itraconazole for oral dosage form production JO: Eur J Pharm Sci http://www.kidney.de/pget.php?&tw=1&pmid=40784664 #FOAvip Semisolid extrusion 3D printing is a manufacturing method that has shown promising results in precise production of patient specific dosage forms. Drug nanocrystals, where the particle size of the drug is in the nanometer range, is an attractive formulation strategy for improving the bioavailability of poorly water-soluble drugs. However, because nanocrystals remain suspended in the semisolid extrusion 3D printing formulation, dispensing of the material might be adversely affected by these particles. Currently, the effect of suspended drug nanocrystals on the semisolid extrusion dispensing precision is not well understood. In this study, dispensing precision was evaluated by analysing the weight variation during semisolid extrusion 3D printing. The formulation base, where itraconazole nanocrystals and nanofibrillated cellulose were added, consisted of polyethylene glycol, hydroxypropyl methylcellulose, and water. It was discovered that nanocrystals improved the dispensing precision compared to the nanocrystal free formulation base. Additionally, nanofibrillated cellulose could be combined with nanocrystals to improve the dispensing precision even further. The dispensing precision of the formulations was found to be linked with the viscosity at the high shear rate region. In conclusion, the data suggests that drug nanocrystal containing oral dosage forms can be precisely manufactured using semisolid extrusion 3D printing, without major indication of drug nanocrystals adversely affecting the dispensing process. Twit Text FOAVip The effect of formulation composition and flow conditions on the robustness of semisolid extrusion 3D printing: a case study on poorly water-soluble itraconazole for oral dosage form production ????Eur J Pharm Sci http://www.kidney.de/pget.php?&tw=1&pmid=40784664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40784664 #FOAvip English Wikipedia <ref>{{Cite pmid|40784664}}</ref> The effect of formulation composition and flow conditions on the robustness of semisolid extrusion 3D printing: a case study on poorly water-soluble itraconazole for oral dosage form production #MMPMID40784664 Junnila A; Henriksson O; Fatemeh A; Immonen E; Emam MF; Kemell M; Pahimanolis N; Mikkonen K; Hirvonen J; Viitala T; Karttunen AP; Peltonen L Eur J Pharm Sci 2025[Aug]; 213 (ä): 107230 PMID40784664show ga Semisolid extrusion 3D printing is a manufacturing method that has shown promising results in precise production of patient specific dosage forms. Drug nanocrystals, where the particle size of the drug is in the nanometer range, is an attractive formulation strategy for improving the bioavailability of poorly water-soluble drugs. However, because nanocrystals remain suspended in the semisolid extrusion 3D printing formulation, dispensing of the material might be adversely affected by these particles. Currently, the effect of suspended drug nanocrystals on the semisolid extrusion dispensing precision is not well understood. In this study, dispensing precision was evaluated by analysing the weight variation during semisolid extrusion 3D printing. The formulation base, where itraconazole nanocrystals and nanofibrillated cellulose were added, consisted of polyethylene glycol, hydroxypropyl methylcellulose, and water. It was discovered that nanocrystals improved the dispensing precision compared to the nanocrystal free formulation base. Additionally, nanofibrillated cellulose could be combined with nanocrystals to improve the dispensing precision even further. The dispensing precision of the formulations was found to be linked with the viscosity at the high shear rate region. In conclusion, the data suggests that drug nanocrystal containing oral dosage forms can be precisely manufactured using semisolid extrusion 3D printing, without major indication of drug nanocrystals adversely affecting the dispensing process. äThe effect of formulation composition and flow conditions on the robus(epmc).pdf DeepDyve Pubget Overpricing