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10.1016/j.ijpharm.2025.126059 http://scihub22266oqcxt.onion/10.1016/j.ijpharm.2025.126059 40784429!ä!40784429 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40784429.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Pharm 2025 ; 683 (ä): 126059 Nephropedia Template TP {{tp|p=40784429|t=2025. Aerosol drug delivery in pediatric airways: in vitro and CFD insights into tongue position and inhalation patterns using soft mist inhalers |pdf=|usr=}}{{40784429}} gab.com Text Aerosol drug delivery in pediatric airways: in vitro and CFD insights into tongue position and inhalation patterns using soft mist inhalers JO: Int J Pharm http://www.kidney.de/pget.php?&tw=1&pmid=40784429 #FOAvip Respiratory diseases such as asthma have a significant impact on children worldwide, underscoring the need for accurate assessments of aerosol drug delivery. This study integrates computational fluid dynamics (CFD) and in vitro experiments to evaluate drug deposition from a soft mist inhaler (SMI) in a pediatric mouth-throat (MT) airway. Large eddy simulation (LES) and the discrete phase model (DPM) were employed in ANSYS Fluent to investigate the effects of various inhalation profiles and tongue positions on droplet behaviour. The numerical results closely matched in vitro data obtained from a next-generation impactor, with a root mean square error (RMSE) of 0.061. We found that the deposition of aerosol medications in pediatric patients was over twice that of adults at an inhalation flow rate of 30 l/min under normal tongue posture. Lowering the tongue position reduced deposition within the mouth and on the device's mouthpiece, while increasing deposition in the throat and at the outlet. Higher flow rates enhanced the retention of small droplets (0.1-2 mum) and broadened the deposition sites. A predictive correlation for mouth deposition was established for Stokes numbers greater than 0.02. Simulating realistic asthma profiles, along with 2-step and 3-step pulsatile inhalation patterns, enhanced the retention of small droplets and decreased the deposition of larger droplets (ranging from 5 to 60 microm). These conditions contributed to reduced mouth deposition and increased drug loss to the mouthpiece. Notably, pulsatile profiles increased tongue deposition, whereas the asthma profile enhanced deposition on the palate wall. Twit Text FOAVip Aerosol drug delivery in pediatric airways: in vitro and CFD insights into tongue position and inhalation patterns using soft mist inhalers ????Int J Pharm http://www.kidney.de/pget.php?&tw=1&pmid=40784429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40784429 #FOAvip English Wikipedia <ref>{{Cite pmid|40784429}}</ref> Aerosol drug delivery in pediatric airways: in vitro and CFD insights into tongue position and inhalation patterns using soft mist inhalers #MMPMID40784429 Sadeghi T; Fatehi P; Pakzad L Int J Pharm 2025[Aug]; 683 (ä): 126059 PMID40784429show ga Respiratory diseases such as asthma have a significant impact on children worldwide, underscoring the need for accurate assessments of aerosol drug delivery. This study integrates computational fluid dynamics (CFD) and in vitro experiments to evaluate drug deposition from a soft mist inhaler (SMI) in a pediatric mouth-throat (MT) airway. Large eddy simulation (LES) and the discrete phase model (DPM) were employed in ANSYS Fluent to investigate the effects of various inhalation profiles and tongue positions on droplet behaviour. The numerical results closely matched in vitro data obtained from a next-generation impactor, with a root mean square error (RMSE) of 0.061. We found that the deposition of aerosol medications in pediatric patients was over twice that of adults at an inhalation flow rate of 30 l/min under normal tongue posture. Lowering the tongue position reduced deposition within the mouth and on the device's mouthpiece, while increasing deposition in the throat and at the outlet. Higher flow rates enhanced the retention of small droplets (0.1-2 mum) and broadened the deposition sites. A predictive correlation for mouth deposition was established for Stokes numbers greater than 0.02. Simulating realistic asthma profiles, along with 2-step and 3-step pulsatile inhalation patterns, enhanced the retention of small droplets and decreased the deposition of larger droplets (ranging from 5 to 60 microm). These conditions contributed to reduced mouth deposition and increased drug loss to the mouthpiece. Notably, pulsatile profiles increased tongue deposition, whereas the asthma profile enhanced deposition on the palate wall. äAerosol drug delivery in pediatric airways: in vitro and CFD insights (epmc).pdf DeepDyve Pubget Overpricing