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10.1161/01.hyp.7.6_pt_2.ii164

http://scihub22266oqcxt.onion/10.1161/01.hyp.7.6_pt_2.ii164
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4077235!ä!4077235

suck abstract from ncbi


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pmid4077235      Hypertension 1985 ; 7 (6 Pt 2): II164-9
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  • Serum lipoproteins during treatment with the antihypertensive agent indapamide #MMPMID4077235
  • Gerber A; Weidmann P; Bianchetti MG; Ferrier C; Laederach K; Mordasini R; Riesen W; Bachmann C
  • Hypertension 1985[Nov]; 7 (6 Pt 2): II164-9 PMID4077235show ga
  • Considering the documented, potentially undesirable influence of various thiazide-type or loop diuretics on serum lipoproteins, we prospectively investigated in 69 men (mean age +/- SEM, 32 +/- 1 years) the metabolic effects of the new diuretic-antihypertensive compound indapamide. Compared to placebo, indapamide (2.5 mg/day) given for 6 to 8 weeks lowered (p less than 0.02 to less than 0.001) blood pressure (supine values from 148/98 +/- 3/2 to 137/93 +/- 3/2) in 29 men with mild to moderate essential hypertension, but not in 40 healthy men. In both groups, significant (p less than 0.05 to less than 0.001) decreases in body weight (-0.8 kg) and plasma potassium (-0.6 mmol/L), and increases in plasma uric acid (+20%), renin activity (+200%), and aldosterone documented good compliance. There were no significant changes in total cholesterol (in all subjects, from 208 +/- 6 to 213 +/- 6 mg/dl), low- or very low-density lipoprotein (VLDL) cholesterol (127 +/- 6 to 129 +/- 6 and 21 +/- 1 to 21 +/- 2 respectively), high-density lipoprotein cholesterol (50 +/- 1 to 51 +/- 1 mg/dl), total triglycerides (Tg) (108 +/- 5 to 112 +/- 6 mg/dl), VLDL-Tg, apoproteins A1 and A2, plasma glucose, epinephrine, norepinephrine, sodium, calcium, magnesium, and creatinine; apoprotein B (84 +/- 2 to 88 +/- 3 mg/dl) and plasma insulin after glucose loading dose tended to be increased minimally. The absence of distinct lipoprotein alterations after short-term indapamide treatment may be of clinical and epidemiological interest.
  • |Adult[MESH]
  • |Antihypertensive Agents/*pharmacology[MESH]
  • |Apoproteins/blood[MESH]
  • |Blood Chemical Analysis[MESH]
  • |Body Weight/drug effects[MESH]
  • |Cholesterol, HDL/blood[MESH]
  • |Diuretics/*pharmacology[MESH]
  • |Drug Evaluation[MESH]
  • |Humans[MESH]
  • |Indapamide/*pharmacology[MESH]
  • |Lipoproteins/*blood[MESH]
  • |Male[MESH]
  • |Prospective Studies[MESH]


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