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10.1002/advs.202500971 http://scihub22266oqcxt.onion/10.1002/advs.202500971 40642872!ä!40642872 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40642872.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Sci+(Weinh) 2025 ; ä (ä): e00971 Nephropedia Template TP {{tp|p=40642872|t=2025. Dysfunctional Decidual CD4(+)T Cells Induce Recurrent Pregnancy Loss via Palmitoylation-Dependent Tim-3 Lysosomal Sorting and Degradation |pdf=|usr=}}{{40642872}} gab.com Text Dysfunctional Decidual CD4(+)T Cells Induce Recurrent Pregnancy Loss via Palmitoylation-Dependent Tim-3 Lysosomal Sorting and Degradation JO: Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=40642872 #FOAvip Palmitoylation is a fully reversible post-translational modification that regulates the functions of various proteins. While its dysregulation has been implicated in numerous pathological processes, there has been scarce researches on palmitoylation changes in proteins associated with recurrent pregnancy loss (RPL). Utilizing palmitoylation proteomics, 3262 proteins are identified with increased palmitoylation and 1577 proteins with decreased palmitoylation in the decidual immune cells from RPL patients compared to those from normal early pregnancies. Reduced palmitoylation by 2-bromopalmitate promoted decidual CD4(+)T (dCD4(+)T) cell tolerance and decrease the resorption rate of abortion-prone mice, suggesting that elevated palmitoylation level may be associated with RPL. The bioinformatics, proteomic, functional and mouse model studies revealed that T cell immunoglobulin domain and mucin domain-3 (Tim-3) is palmitoylated by ZDHHC3 on cysteine 9 residue. This palmitoylated-Tim-3 subsequently bound to sortilin and was directed to lysosome for degradation, leading to decreased expression of Tim-3 and the dysfunction of dCD4(+)T cells, ultimately resulting in fetal loss. We elucidated a pivotal role for dynamic palmitoylation in RPL and uncovered a novel mechanism governing Tim-3 regulation. Given that Tim-3 dysregulation is frequently linked to RPL, our findings may have important implications for understanding the etiology of RPL and developing targeted therapy of RPL. Twit Text FOAVip Dysfunctional Decidual CD4(+)T Cells Induce Recurrent Pregnancy Loss via Palmitoylation-Dependent Tim-3 Lysosomal Sorting and Degradation ????Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=40642872 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40642872 #FOAvip English Wikipedia <ref>{{Cite pmid|40642872}}</ref> Dysfunctional Decidual CD4(+)T Cells Induce Recurrent Pregnancy Loss via Palmitoylation-Dependent Tim-3 Lysosomal Sorting and Degradation #MMPMID40642872 Cui L; Meng X; Luo Y; Qian J; Sun F; Qiu M; Wang S Adv Sci (Weinh) 2025[Jul]; ä (ä): e00971 PMID40642872show ga Palmitoylation is a fully reversible post-translational modification that regulates the functions of various proteins. While its dysregulation has been implicated in numerous pathological processes, there has been scarce researches on palmitoylation changes in proteins associated with recurrent pregnancy loss (RPL). Utilizing palmitoylation proteomics, 3262 proteins are identified with increased palmitoylation and 1577 proteins with decreased palmitoylation in the decidual immune cells from RPL patients compared to those from normal early pregnancies. Reduced palmitoylation by 2-bromopalmitate promoted decidual CD4(+)T (dCD4(+)T) cell tolerance and decrease the resorption rate of abortion-prone mice, suggesting that elevated palmitoylation level may be associated with RPL. The bioinformatics, proteomic, functional and mouse model studies revealed that T cell immunoglobulin domain and mucin domain-3 (Tim-3) is palmitoylated by ZDHHC3 on cysteine 9 residue. This palmitoylated-Tim-3 subsequently bound to sortilin and was directed to lysosome for degradation, leading to decreased expression of Tim-3 and the dysfunction of dCD4(+)T cells, ultimately resulting in fetal loss. We elucidated a pivotal role for dynamic palmitoylation in RPL and uncovered a novel mechanism governing Tim-3 regulation. Given that Tim-3 dysregulation is frequently linked to RPL, our findings may have important implications for understanding the etiology of RPL and developing targeted therapy of RPL. äDysfunctional Decidual CD4(+)T Cells Induce Recurrent Pregnancy Loss v(epmc).pdf DeepDyve Pubget Overpricing