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10.1242/dmm.052177 http://scihub22266oqcxt.onion/10.1242/dmm.052177 40642792!ä!40642792 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40642792.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Dis+Model+Mech 2025 ; ä (ä): ä Nephropedia Template TP {{tp|p=40642792|t=2025. Novel murine cell lines with defined mutations model different histological subtypes of epithelial ovarian cancer |pdf=|usr=}}{{40642792}} gab.com Text Novel murine cell lines with defined mutations model different histological subtypes of epithelial ovarian cancer JO: Dis Model Mech http://www.kidney.de/pget.php?&tw=1&pmid=40642792 #FOAvip Preclinical modeling of epithelial ovarian cancer in immune competent mice progressing to orthotopic, spontaneous tumors is challenging, requiring multiple genetic modifications in the host. Transplantable models using cell lines are easier to implement, given that they reproduce the key disease characteristics. To create new in vivo ovarian tumor models, we have generated a total of 28 murine ovarian cancer cell lines with distinct genetic traits such as deletion of Trp53, activation of KrasG12D, deletion of Pten or KrasG12D/Pten-/- combination. Two distinct Trp53 null cell lines recapitulate high grade serous histology when orthotopically injected in immune competent, syngeneic hosts. Cells with Pten deletion trigger high grade endometrioid tumors, and cells with dual KrasG12D activation and Pten deletion model carcinosarcoma. The cells express different tumor antigens, secrete varying levels of cytokines and chemokines, and trigger tumors with diverse inflammation profiles and various intratumoral T and B lymphocyte infiltration patterns. RNAseq data from 16 cell lines reveal the gene expression profile across distinct models with different histotypes. This versatile collection of murine cell lines supports translationally relevant studies in ovarian cancer. Twit Text FOAVip Novel murine cell lines with defined mutations model different histological subtypes of epithelial ovarian cancer ????Dis Model Mech http://www.kidney.de/pget.php?&tw=1&pmid=40642792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40642792 #FOAvip English Wikipedia <ref>{{Cite pmid|40642792}}</ref> Novel murine cell lines with defined mutations model different histological subtypes of epithelial ovarian cancer #MMPMID40642792 Zhang L; Fang Y; Uygun I; Li D; Strange M; Zaidi SK; Wang W; Knight J; Radolec M; Elishaev E; Brozick JF; Edwards A; Tseng G; Cascio S; Buckanovich R; Edwards RP; Vlad AM Dis Model Mech 2025[Jul]; ä (ä): ä PMID40642792show ga Preclinical modeling of epithelial ovarian cancer in immune competent mice progressing to orthotopic, spontaneous tumors is challenging, requiring multiple genetic modifications in the host. Transplantable models using cell lines are easier to implement, given that they reproduce the key disease characteristics. To create new in vivo ovarian tumor models, we have generated a total of 28 murine ovarian cancer cell lines with distinct genetic traits such as deletion of Trp53, activation of KrasG12D, deletion of Pten or KrasG12D/Pten-/- combination. Two distinct Trp53 null cell lines recapitulate high grade serous histology when orthotopically injected in immune competent, syngeneic hosts. Cells with Pten deletion trigger high grade endometrioid tumors, and cells with dual KrasG12D activation and Pten deletion model carcinosarcoma. The cells express different tumor antigens, secrete varying levels of cytokines and chemokines, and trigger tumors with diverse inflammation profiles and various intratumoral T and B lymphocyte infiltration patterns. RNAseq data from 16 cell lines reveal the gene expression profile across distinct models with different histotypes. This versatile collection of murine cell lines supports translationally relevant studies in ovarian cancer. äNovel murine cell lines with defined mutations model different histolo(epmc).pdf DeepDyve Pubget Overpricing