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10.1186/s13075-025-03608-6 http://scihub22266oqcxt.onion/10.1186/s13075-025-03608-6 40640860!ä!40640860 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40640860.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Arthritis+Res+Ther 2025 ; 27 (1): 147 Nephropedia Template TP {{tp|p=40640860|t=2025. Investigation of serum biomarkers in rheumatoid and psoriatic arthritis patients for disease-specific signatures |pdf=|usr=}}{{40640860}} gab.com Text Investigation of serum biomarkers in rheumatoid and psoriatic arthritis patients for disease-specific signatures JO: Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=40640860 #FOAvip BACKGROUND: Rheumatoid arthritis (RA) and Psoriatic arthritis (PsA) are systemic auto-immune diseases of unknown aetiology that lead to systemic inflammation and synovial joint destruction. Identification of specific serum proteins that selectively regulate these diseases, or which precede disease development could have great potential as disease biomarkers and predictors. METHODS: Serum levels of C-reactive protein (CRP), sICAM-1, sVCAM-1, Serum amyloid A (SAA), Matrix metalloproteinases (MMPs 1, 3 and 9) and metabolic markers: Active Glucose-dependent Insulinotropic polypeptide (GIP), active Glucagon-like peptide-1 (GLP-1), C-Peptide, Glucagon, Insulin, Leptin, Pancreatic Polypeptide (PP) were measured by Meso Scale Discovery (MSD) multiplex analysis assay. RESULTS: Serum levels of sICAM-1, MMP1, MMP3, PP, c-Peptide, CRP and SAA were specifically upregulated in RA, but not in PsA disease, displaying high sensitivity (ROC curves). In the early phase of the disease, these markers may be suitable for discriminating RA from PsA patients. Differences in sex, BMI, and disease activity were observed. This is the first study which directly compare serum metabolic markers between diseases and identifies specific disease signatures between RA and PsA. In addition, this study identified that CRP, SAA, GLP-1, GIP-1, Leptin and PP serum protein precede disease onset, as they are already altered in the serum of 'individuals at risk' of developing RA. Of these, CRP, SAA, Leptin and PP might predict IAR conversion to RA(+), thus making them suitable candidates for disease prediction. CONCLUSIONS: Altogether, this study identifies selective serum markers associated with RA and PsA, which are pathotype-specific and are predictors of RA disease onset. Twit Text FOAVip Investigation of serum biomarkers in rheumatoid and psoriatic arthritis patients for disease-specific signatures ????Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=40640860 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40640860 #FOAvip English Wikipedia <ref>{{Cite pmid|40640860}}</ref> Investigation of serum biomarkers in rheumatoid and psoriatic arthritis patients for disease-specific signatures #MMPMID40640860 Veale JD; Gorman A; Veale DJ; Fearon U; Orr C; Marzaioli V Arthritis Res Ther 2025[Jul]; 27 (1): 147 PMID40640860show ga BACKGROUND: Rheumatoid arthritis (RA) and Psoriatic arthritis (PsA) are systemic auto-immune diseases of unknown aetiology that lead to systemic inflammation and synovial joint destruction. Identification of specific serum proteins that selectively regulate these diseases, or which precede disease development could have great potential as disease biomarkers and predictors. METHODS: Serum levels of C-reactive protein (CRP), sICAM-1, sVCAM-1, Serum amyloid A (SAA), Matrix metalloproteinases (MMPs 1, 3 and 9) and metabolic markers: Active Glucose-dependent Insulinotropic polypeptide (GIP), active Glucagon-like peptide-1 (GLP-1), C-Peptide, Glucagon, Insulin, Leptin, Pancreatic Polypeptide (PP) were measured by Meso Scale Discovery (MSD) multiplex analysis assay. RESULTS: Serum levels of sICAM-1, MMP1, MMP3, PP, c-Peptide, CRP and SAA were specifically upregulated in RA, but not in PsA disease, displaying high sensitivity (ROC curves). In the early phase of the disease, these markers may be suitable for discriminating RA from PsA patients. Differences in sex, BMI, and disease activity were observed. This is the first study which directly compare serum metabolic markers between diseases and identifies specific disease signatures between RA and PsA. In addition, this study identified that CRP, SAA, GLP-1, GIP-1, Leptin and PP serum protein precede disease onset, as they are already altered in the serum of 'individuals at risk' of developing RA. Of these, CRP, SAA, Leptin and PP might predict IAR conversion to RA(+), thus making them suitable candidates for disease prediction. CONCLUSIONS: Altogether, this study identifies selective serum markers associated with RA and PsA, which are pathotype-specific and are predictors of RA disease onset. |*Arthritis, Psoriatic/blood/diagnosis[MESH] |*Arthritis, Rheumatoid/blood/diagnosis[MESH] |*Biomarkers/blood[MESH] |Adult[MESH] |Aged[MESH] |C-Reactive Protein/metabolism[MESH] |Female[MESH] |Humans[MESH] |Male[MESH]Investigation of serum biomarkers in rheumatoid and psoriatic arthriti(epmc).pdf DeepDyve Pubget Overpricing