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10.1186/s13052-025-02029-0 http://scihub22266oqcxt.onion/10.1186/s13052-025-02029-0 40611140!ä!40611140 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40611140.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ital+J+Pediatr 2025 ; 51 (1): 208 Nephropedia Template TP {{tp|p=40611140|t=2025. Case report: anti-fibrillarin autoantibodies induced by viral molecular mimicry in a paediatric patient |pdf=|usr=}}{{40611140}} gab.com Text Case report: anti-fibrillarin autoantibodies induced by viral molecular mimicry in a paediatric patient JO: Ital J Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=40611140 #FOAvip BACKGROUND: Anti-fibrillarin autoantibodies (AFA) as serological hallmarks of systemic sclerosis, mainly react with epitopes arranged in the NH2-(aa-1-80) and COOH-terminal-(aa-276-321)-domains of fibrillarin. Interestingly, the fibrillarin NH2-hexapeptide sequence is shared with an Epstein-Barr-virus (EBV)-encoded nuclear antigen. CASE PRESENTATION: We herein report a case of a 14-year-old girl presenting with a history of vomiting, sore throat, arthralgias and fever. Laboratory tests revealed leukocytosis, an increased level of CRP, transaminases and total/direct bilirubin. On further investigation, a positivity of ANA testing showing a clumpy nucleolar indirect immunofluorescence (AC-9) pattern on HEp-2000 substrate, due to anti-fibrillarin antibodies, was found. Concomitantly, high concentrations of EBV-VCA-IgM and a slight increase of EBV-VCA-IgG were detected, helping establish a diagnosis of ongoing EBV infection. After a follow-up of six months, all autoimmunity tests were repeated, and together with infection resolution, the negativity of ANA was determined, confirming the transient nature of the autoimmune phenomenon. CONCLUSIONS: Our findings confirm how molecular mimicry plays an important role in the viral-induced autoimmunity. Given the significant homology between fibrillarin and EBV protein sequences, caution in interpreting AFA positivity is suggested, especially in pediatric patients without clinical evidences of an autoimmune condition, and a simultaneous screening for EBV infections is recommended. Twit Text FOAVip Case report: anti-fibrillarin autoantibodies induced by viral molecular mimicry in a paediatric patient ????Ital J Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=40611140 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40611140 #FOAvip English Wikipedia <ref>{{Cite pmid|40611140}}</ref> Case report: anti-fibrillarin autoantibodies induced by viral molecular mimicry in a paediatric patient #MMPMID40611140 Autilio C; Pecoraro R; Pafundi V; Manieri S; Tipo V; Martemucci L; Carbone T Ital J Pediatr 2025[Jul]; 51 (1): 208 PMID40611140show ga BACKGROUND: Anti-fibrillarin autoantibodies (AFA) as serological hallmarks of systemic sclerosis, mainly react with epitopes arranged in the NH2-(aa-1-80) and COOH-terminal-(aa-276-321)-domains of fibrillarin. Interestingly, the fibrillarin NH2-hexapeptide sequence is shared with an Epstein-Barr-virus (EBV)-encoded nuclear antigen. CASE PRESENTATION: We herein report a case of a 14-year-old girl presenting with a history of vomiting, sore throat, arthralgias and fever. Laboratory tests revealed leukocytosis, an increased level of CRP, transaminases and total/direct bilirubin. On further investigation, a positivity of ANA testing showing a clumpy nucleolar indirect immunofluorescence (AC-9) pattern on HEp-2000 substrate, due to anti-fibrillarin antibodies, was found. Concomitantly, high concentrations of EBV-VCA-IgM and a slight increase of EBV-VCA-IgG were detected, helping establish a diagnosis of ongoing EBV infection. After a follow-up of six months, all autoimmunity tests were repeated, and together with infection resolution, the negativity of ANA was determined, confirming the transient nature of the autoimmune phenomenon. CONCLUSIONS: Our findings confirm how molecular mimicry plays an important role in the viral-induced autoimmunity. Given the significant homology between fibrillarin and EBV protein sequences, caution in interpreting AFA positivity is suggested, especially in pediatric patients without clinical evidences of an autoimmune condition, and a simultaneous screening for EBV infections is recommended. |*Autoantibodies/immunology/blood[MESH] |*Chromosomal Proteins, Non-Histone/immunology[MESH] |*Epstein-Barr Virus Infections/immunology/diagnosis[MESH] |*Herpesvirus 4, Human/immunology[MESH] |*Molecular Mimicry/immunology[MESH] |Adolescent[MESH] |Female[MESH]Case report: anti-fibrillarin autoantibodies induced by viral molecula(epmc).pdf DeepDyve Pubget Overpricing