Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s12967-025-06756-0 http://scihub22266oqcxt.onion/10.1186/s12967-025-06756-0 40611132!ä!40611132 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40611132.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Transl+Med 2025 ; 23 (1): 737 Nephropedia Template TP {{tp|p=40611132|t=2025. Role of senescent CD4(+) T cells in breakthrough infection of the new variant strain of SARS-CoV-2 in elderly patients |pdf=|usr=}}{{40611132}} gab.com Text Role of senescent CD4(+) T cells in breakthrough infection of the new variant strain of SARS-CoV-2 in elderly patients JO: J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=40611132 #FOAvip BACKGROUND: In late 2022, Beijing, China saw a large-scale BF.7 Omicron variant breakthrough infection. However, the impact of COVID-19 vaccines on elderly breakthrough-infected patients' antibodies and immune cells response was unclear. METHODS: We recruited 329 inpatients over 65 with BF.7 breakthrough infections. We analyzed the link between vaccination and survival in 67 sampled patients, investigating changes in antibody levels, cytokine profiles, as well as immune phenotypes. RESULTS: Experiments revealed that while vaccination could raise antibody levels in the elderly, it showed no significant neutralizing activity against the emerging COVID-19 variant XBB. Flow cytometry showed vaccination increased the proportion of CD4(+) senescent T cells. Moreover, we found that elevated frequencies of CD4(+) Tsens cells were associated with reduced antigen-specific CD4(+) T cell activation, diminished IL-2 production, and lower proportions of Tfh cells, which ultimately leading to impaired neutralizing antibody production, particularly against new emerging variants. CONCLUSIONS: We found the immunological efficacy of inactivated vaccines in elderly patients is influenced by the proportion of CD4(+) senescent T cells. Future elderly vaccination strategies need optimization in dose number and timing, and future vaccine design should aim to minimize the generation of CD4(+) senescent T cells. Twit Text FOAVip Role of senescent CD4(+) T cells in breakthrough infection of the new variant strain of SARS-CoV-2 in elderly patients ????J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=40611132 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40611132 #FOAvip English Wikipedia <ref>{{Cite pmid|40611132}}</ref> Role of senescent CD4(+) T cells in breakthrough infection of the new variant strain of SARS-CoV-2 in elderly patients #MMPMID40611132 Liang Z; Zhang H; Xu L; Li N; Yin Z; Sun Y; Shen N; Guo Z; Wang Y; Xue L; Zhang J; Zeng L; Yang J; Zhan S J Transl Med 2025[Jul]; 23 (1): 737 PMID40611132show ga BACKGROUND: In late 2022, Beijing, China saw a large-scale BF.7 Omicron variant breakthrough infection. However, the impact of COVID-19 vaccines on elderly breakthrough-infected patients' antibodies and immune cells response was unclear. METHODS: We recruited 329 inpatients over 65 with BF.7 breakthrough infections. We analyzed the link between vaccination and survival in 67 sampled patients, investigating changes in antibody levels, cytokine profiles, as well as immune phenotypes. RESULTS: Experiments revealed that while vaccination could raise antibody levels in the elderly, it showed no significant neutralizing activity against the emerging COVID-19 variant XBB. Flow cytometry showed vaccination increased the proportion of CD4(+) senescent T cells. Moreover, we found that elevated frequencies of CD4(+) Tsens cells were associated with reduced antigen-specific CD4(+) T cell activation, diminished IL-2 production, and lower proportions of Tfh cells, which ultimately leading to impaired neutralizing antibody production, particularly against new emerging variants. CONCLUSIONS: We found the immunological efficacy of inactivated vaccines in elderly patients is influenced by the proportion of CD4(+) senescent T cells. Future elderly vaccination strategies need optimization in dose number and timing, and future vaccine design should aim to minimize the generation of CD4(+) senescent T cells. |*CD4-Positive T-Lymphocytes/immunology[MESH] |*COVID-19/immunology/virology/prevention & control[MESH] |*Cellular Senescence/immunology[MESH] |*SARS-CoV-2/immunology[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Neutralizing/immunology/blood[MESH] |Antibodies, Viral/immunology/blood[MESH] |Breakthrough Infections[MESH] |COVID-19 Vaccines/immunology[MESH] |China[MESH] |Female[MESH] |Humans[MESH] |Male[MESH]Role of senescent CD4(+) T cells in breakthrough infection of the new (epmc).pdf DeepDyve Pubget Overpricing