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10.1186/s12974-025-03499-z http://scihub22266oqcxt.onion/10.1186/s12974-025-03499-z 40611130!12226897!40611130     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40611130.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Neuroinflammation 2025 ; 22 (1): 173 Nephropedia Template TP {{tp|p=40611130|t=2025. Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration |pdf=|usr=}}{{40611130}} gab.com Text Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration JO: J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=40611130 #FOAvip Age-related macular degeneration (AMD), a multifactorial type of retinal degeneration represents the most common cause for blindness in elderly. Polymorphisms in complement factor-H increase, while absence of factor-H-related protein-1 (FHR1) decreases the AMD risk, currently explained by their opposing relationship. Here we identify a FHR1-driven pathway fostering chronic cellular inflammation. FHR1 accumulates below the retinal pigment epithelium (RPE) in AMD donor tissue and similarly the murine homolog, muFHR1 is abundant in three AMD-relevant mouse models. These mouse models express the muFHR1 receptor EGF-like module-containing mucin-like hormone receptor 1 (Emr1) on the RPE and on invading mononuclear phagocytes (MP), where both cells form clusters via muFHR1/Emr1. FHR1 ignited EMR2-dependent Ca(2+)-signals and gene expression in both human RPE cell line and in vivo where muFHR1 affects Emr1(+) cells (RPE and MP) gene expression shown by RNAseq analysis. As muFHR1 deletion in mice revealed significantly reduced MP invasion and neoangiogenesis in laser-induced choroidal neovascularization, we hypothesize that FHR1 accumulates, stabilizes and activates MP in the stage of RPE degeneration. Twit Text FOAVip Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration ????J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=40611130 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40611130 #FOAvip English Wikipedia <ref>{{Cite pmid|40611130}}</ref> Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration #MMPMID40611130 Sekulic A; Herr SM; Mulfaul K; Pompos IM; Winkler S; Dietrich C; Obermayer B; Mullins RF; Conrad T; Zipfel PF; Sennlaub F; Skerka C; Strauss O J Neuroinflammation 2025[Jul]; 22 (1): 173 PMID40611130show ga Age-related macular degeneration (AMD), a multifactorial type of retinal degeneration represents the most common cause for blindness in elderly. Polymorphisms in complement factor-H increase, while absence of factor-H-related protein-1 (FHR1) decreases the AMD risk, currently explained by their opposing relationship. Here we identify a FHR1-driven pathway fostering chronic cellular inflammation. FHR1 accumulates below the retinal pigment epithelium (RPE) in AMD donor tissue and similarly the murine homolog, muFHR1 is abundant in three AMD-relevant mouse models. These mouse models express the muFHR1 receptor EGF-like module-containing mucin-like hormone receptor 1 (Emr1) on the RPE and on invading mononuclear phagocytes (MP), where both cells form clusters via muFHR1/Emr1. FHR1 ignited EMR2-dependent Ca(2+)-signals and gene expression in both human RPE cell line and in vivo where muFHR1 affects Emr1(+) cells (RPE and MP) gene expression shown by RNAseq analysis. As muFHR1 deletion in mice revealed significantly reduced MP invasion and neoangiogenesis in laser-induced choroidal neovascularization, we hypothesize that FHR1 accumulates, stabilizes and activates MP in the stage of RPE degeneration. |*Complement C3b Inactivator Proteins/metabolism/genetics[MESH] |*Inflammation/metabolism/pathology/genetics[MESH] |*Macular Degeneration/metabolism/pathology/genetics[MESH] |Animals[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Mice, Transgenic[MESH]Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in (epmc).pdf DeepDyve Pubget Overpricing