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10.1186/s12933-025-02774-w http://scihub22266oqcxt.onion/10.1186/s12933-025-02774-w 40611109!ä!40611109 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40611109.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cardiovasc+Diabetol 2025 ; 24 (1): 265 Nephropedia Template TP {{tp|p=40611109|t=2025. Cardiometabolic heart failure with preserved ejection fraction: from molecular signatures to personalized treatment |pdf=|usr=}}{{40611109}} gab.com Text Cardiometabolic heart failure with preserved ejection fraction: from molecular signatures to personalized treatment JO: Cardiovasc Diabetol http://www.kidney.de/pget.php?&tw=1&pmid=40611109 #FOAvip Heart failure with preserved ejection fraction (HFpEF) represents nearly half of all heart failure cases globally. The increased prevalence of cardiometabolic disease, driven by unhealthy lifestyles, has led to a growing population of people developing the so called "cardiometabolic HFpEF (cmHFpEF)" phenotype. This condition represents an end stage cardiometabolic phenotype which results from the clustering of metabolic stress (obesity), hemodynamic stress (hypertension), immune activation, and systemic inflammation. This form of HFpEF is preceded by a "metabolic cardiomyopathy" phenotype, characterized by myocardial metabolic remodeling, rewiring of lipid metabolism, and inflammation eventually fostering left ventricular hypertrophy, diastolic dysfunction and atrial dilatation. Recent work over the last years has unveiled the molecular cues underpinning cmHFpEF pathogenesis thus contributing to the identification of novel therapeutic approaches to treat this complex syndrome. The present review provides an overview of recent advances in cmHFpEF biology and pathophysiology with particular emphasis on the following aspects: (i) metabolic alterations associated with cmHFpEF; (ii) changes of the immune landscape; (iii) microvascular dysfunction; (iv) inflammation; (v) chromatin remodeling. Additionally, we will discuss potential mechanisms-based therapeutic strategies to tackle this growing health concern. Twit Text FOAVip Cardiometabolic heart failure with preserved ejection fraction: from molecular signatures to personalized treatment ????Cardiovasc Diabetol http://www.kidney.de/pget.php?&tw=1&pmid=40611109 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40611109 #FOAvip English Wikipedia <ref>{{Cite pmid|40611109}}</ref> Cardiometabolic heart failure with preserved ejection fraction: from molecular signatures to personalized treatment #MMPMID40611109 Gorica E; Geiger MA; Di Venanzio L; Atzemian N; Kleeberger JA; Grigorian D; Mongelli A; Emini Veseli B; Mohammed SA; Ruschitzka F; Flammer AJ; Niederseer D; Costantino S; Paneni F Cardiovasc Diabetol 2025[Jul]; 24 (1): 265 PMID40611109show ga Heart failure with preserved ejection fraction (HFpEF) represents nearly half of all heart failure cases globally. The increased prevalence of cardiometabolic disease, driven by unhealthy lifestyles, has led to a growing population of people developing the so called "cardiometabolic HFpEF (cmHFpEF)" phenotype. This condition represents an end stage cardiometabolic phenotype which results from the clustering of metabolic stress (obesity), hemodynamic stress (hypertension), immune activation, and systemic inflammation. This form of HFpEF is preceded by a "metabolic cardiomyopathy" phenotype, characterized by myocardial metabolic remodeling, rewiring of lipid metabolism, and inflammation eventually fostering left ventricular hypertrophy, diastolic dysfunction and atrial dilatation. Recent work over the last years has unveiled the molecular cues underpinning cmHFpEF pathogenesis thus contributing to the identification of novel therapeutic approaches to treat this complex syndrome. The present review provides an overview of recent advances in cmHFpEF biology and pathophysiology with particular emphasis on the following aspects: (i) metabolic alterations associated with cmHFpEF; (ii) changes of the immune landscape; (iii) microvascular dysfunction; (iv) inflammation; (v) chromatin remodeling. Additionally, we will discuss potential mechanisms-based therapeutic strategies to tackle this growing health concern. |*Energy Metabolism/drug effects[MESH] |*Heart Failure/physiopathology/metabolism/therapy/epidemiology/genetics[MESH] |*Metabolic Syndrome/physiopathology/epidemiology/therapy/metabolism/genetics[MESH] |*Precision Medicine[MESH] |*Stroke Volume/drug effects[MESH] |*Ventricular Function, Left/drug effects[MESH] |Animals[MESH] |Cardiometabolic Risk Factors[MESH] |Humans[MESH] |Inflammation Mediators/metabolism[MESH] |Myocardium/metabolism/pathology[MESH] |Phenotype[MESH]Cardiometabolic heart failure with preserved ejection fraction: from m(epmc).pdf DeepDyve Pubget Overpricing