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10.1093/jleuko/qiaf064 http://scihub22266oqcxt.onion/10.1093/jleuko/qiaf064 40590124!ä!40590124 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40590124.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Leukoc+Biol 2025 ; 117 (6): ä Nephropedia Template TP {{tp|p=40590124|t=2025. Early increased monocyte-to-lymphocyte ratio as a potential biomarker of bacterial sepsis in patients with severe COVID-19 |pdf=|usr=}}{{40590124}} gab.com Text Early increased monocyte-to-lymphocyte ratio as a potential biomarker of bacterial sepsis in patients with severe COVID-19 JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=40590124 #FOAvip Monocytes are pivotal during inflammation. Sepsis added to COVID-19 increases mortality and inflammation. However, the role of monocytes in this condition is unclear. Our aim was to determine monocyte frequencies and HLA-DR expression related to size distribution in patients with severe COVID-19 with or without sepsis. Twenty-nine patients with COVID-19, 9 patients with COVID-19 + sepsis, and 11 non-COVID nonseptic volunteers were recruited. Patients with COVID-19 + sepsis had increased monocyte count (P = 0.004) and monocyte-to-lymphocyte ratio (MLR, P = 0.01) prior to bacterial sepsis development. The monocyte-to-lymphocyte ratio had an area under the curve of 77.8%, suggesting its potential utility in predicting bacterial sepsis up to 21 d before positive culture. In these patients, smaller intermediate and nonclassical monocytes expressed higher levels of HLA-DR (P < 0.05). Diminished HLA-DR expression in bigger monocytes was associated with an increase in severity and inflammatory markers (r2 values equal to or higher than +/-0.4, P < 0.05). Our results suggest that the monocyte-to-lymphocyte ratio could be a potential early marker for bacterial sepsis development in patients with severe COVID-19. Twit Text FOAVip Early increased monocyte-to-lymphocyte ratio as a potential biomarker of bacterial sepsis in patients with severe COVID-19 ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=40590124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40590124 #FOAvip English Wikipedia <ref>{{Cite pmid|40590124}}</ref> Early increased monocyte-to-lymphocyte ratio as a potential biomarker of bacterial sepsis in patients with severe COVID-19 #MMPMID40590124 Basilio-Galvez E; Madera-Sandoval RL; Cerbulo-Vazquez A; Prieto-Chavez JL; Cabrera-Rivera GL; Garcia-de la Rosa MT; Miranda-Cruz PE; Juarez-Palacios JE; Garcia-Rodriguez J; Vazquez-Estrada J; Lima-Salinas V; Alba-Lugo D; Anda-Garay JC; Macias-Gutierrez AY; Martinez-Ascencio LE; Lopez-Teofilo A; Romero-Gutierrez L; Sanchez-Hurtado LA; Avila-Alberto D; Rivas N; Lopez-Macias C; Ferat-Osorio EA; Arriaga-Pizano LA J Leukoc Biol 2025[Jun]; 117 (6): ä PMID40590124show ga Monocytes are pivotal during inflammation. Sepsis added to COVID-19 increases mortality and inflammation. However, the role of monocytes in this condition is unclear. Our aim was to determine monocyte frequencies and HLA-DR expression related to size distribution in patients with severe COVID-19 with or without sepsis. Twenty-nine patients with COVID-19, 9 patients with COVID-19 + sepsis, and 11 non-COVID nonseptic volunteers were recruited. Patients with COVID-19 + sepsis had increased monocyte count (P = 0.004) and monocyte-to-lymphocyte ratio (MLR, P = 0.01) prior to bacterial sepsis development. The monocyte-to-lymphocyte ratio had an area under the curve of 77.8%, suggesting its potential utility in predicting bacterial sepsis up to 21 d before positive culture. In these patients, smaller intermediate and nonclassical monocytes expressed higher levels of HLA-DR (P < 0.05). Diminished HLA-DR expression in bigger monocytes was associated with an increase in severity and inflammatory markers (r2 values equal to or higher than +/-0.4, P < 0.05). Our results suggest that the monocyte-to-lymphocyte ratio could be a potential early marker for bacterial sepsis development in patients with severe COVID-19. |*COVID-19/complications/blood/immunology[MESH] |*Lymphocytes/pathology/immunology[MESH] |*Monocytes/pathology/immunology[MESH] |*SARS-CoV-2[MESH] |*Sepsis/blood/immunology/diagnosis[MESH] |Adult[MESH] |Aged[MESH] |Biomarkers/blood[MESH] |Female[MESH] |HLA-DR Antigens[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH]Early increased monocyte-to-lymphocyte ratio as a potential biomarker (epmc).pdf DeepDyve Pubget Overpricing