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10.1097/RLU.0000000000006026

http://scihub22266oqcxt.onion/10.1097/RLU.0000000000006026
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40590121!ä!40590121

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suck abstract from ncbi


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pmid40590121      Clin+Nucl+Med 2025 ; ä (ä): ä
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  • 6-Deoxy-6- 18F Fluoro-L-Ascorbic Acid PET/CT in the Detection of Lymph Node Metastases for Postoperative Differentiated Thyroid Cancer Patients: Using Histopathology as Reference Standard #MMPMID40590121
  • Long Y; Ge S; Xu X; Jiang K; Zhang Y; Wu R; Zhang X; Liang J; Liu J; He Q; Lv W; Zhang X; Zha Z
  • Clin Nucl Med 2025[Jul]; ä (ä): ä PMID40590121show ga
  • BACKGROUND: 6-Deoxy-6-[18F]fluoro-L-ascorbic acid ([18F]FAA) is a radioisotope-labeled analogue of ascorbic acid (AA), designed to investigate oxidative stress and AA accumulation in vivo by PET imaging. It has also been reported as a promising radiotracer for tumor detection, particularly in metastatic differentiated thyroid cancer (DTC). PURPOSE: This study aimed to evaluate the diagnostic potential of [18F]FAA in detecting lymph node metastases in postoperative DTC patients. METHODS: Patients who have undergone thyroidectomy for DTC and are either preparing for 131I therapy or undergoing follow-up examinations were prospectively enrolled and underwent [18F]FAA PET/CT from September 2023 to November 2023. Histopathologic results served as gold standard for final diagnosis. RESULTS: A total of 70 patients [mean age, 40.5 y+/-12.0 (SD); 23 men] with pathologically confirmed DTC were enrolled. At patient-based analysis, [18F]FAA PET/CT detected positive lymph nodes in all patients, with an accuracy of 92.9% (65/70). At lesion-based analysis of patients who underwent central and/or lateral cervical lymph node dissection, the accuracy of [18F]FAA PET/CT were 94.3% (460/488). The SUVmax and TBR of lymph node metastases were significantly higher than normal lymph nodes (mean SUVmax, 8.3+/-4.6 vs. 2.0+/-1.5, P<0.0001; mean TBR, 3.6+/-2.2 vs. 0.9+/-0.7, P<0.0001). CONCLUSIONS: [18F]FAA PET/CT can be used in the detection of postoperative cervical lymph node metastases in DTC. It may serve as a valuable tool for risk stratification and radioactive iodine treatment decision-making of postoperative DTC.
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