Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1128/msystems.00690-25 http://scihub22266oqcxt.onion/10.1128/msystems.00690-25 40586598!ä!40586598 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40586598.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       mSystems 2025 ; ä (ä): e0069025 Nephropedia Template TP {{tp|p=40586598|t=2025. Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources |pdf=|usr=}}{{40586598}} gab.com Text Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources JO: mSystems http://www.kidney.de/pget.php?&tw=1&pmid=40586598 #FOAvip Cells choose between alternative pathways in metabolic networks under diverse environmental conditions, but the principles governing the choice are insufficiently understood, especially in response to dynamically changing conditions. Here, we observed that the lactic acid bacterium Bacillus coagulans displayed homolactic fermentation on glucose or trehalose as the sole carbon source but transitioned from homolactic to heterolactic fermentation during the hierarchical utilization of glucose and trehalose when growing on the mixture. We simulated the observation by dynamic minimization of reallocation of the proteome (dMORP) using an enzyme-constrained genome-scale metabolic model, which coincided with our omics data. Moreover, we evolved strains to co-utilize mixed carbon sources and repress the choice of heterolactic fermentation, and the dynamics after co-utilization of carbon sources were also captured by dMORP. Altogether, the findings suggest that upon environmental changes, bacteria tend to minimize proteome reallocation and accordingly adjust metabolism, and dMORP would be useful in simulating cellular dynamics.IMPORTANCERedundancy in metabolic networks empowers cells to choose between distinct metabolic strategies under changing environments. However, what drives the cellular choice remains poorly understood. We hypothesized that in response to rapid environmental changes, cells might minimize reallocation of the proteome and accordingly adjust metabolism. We found that this hypothesis could interpret a metabolic transition in the lactic acid bacterium Bacillus coagulans during the hierarchical utilization of glucose and trehalose, which was validated using systems biology approaches. Furthermore, we presented a framework with the objective function of minimizing proteome allocation, allowing for the simulation and understanding of cellular responses to dynamic perturbations. Twit Text FOAVip Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources ????mSystems http://www.kidney.de/pget.php?&tw=1&pmid=40586598 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40586598 #FOAvip English Wikipedia <ref>{{Cite pmid|40586598}}</ref> Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources #MMPMID40586598 Liu Z; Chen M; Hu J; Wang Y; Chen Y mSystems 2025[Jun]; ä (ä): e0069025 PMID40586598show ga Cells choose between alternative pathways in metabolic networks under diverse environmental conditions, but the principles governing the choice are insufficiently understood, especially in response to dynamically changing conditions. Here, we observed that the lactic acid bacterium Bacillus coagulans displayed homolactic fermentation on glucose or trehalose as the sole carbon source but transitioned from homolactic to heterolactic fermentation during the hierarchical utilization of glucose and trehalose when growing on the mixture. We simulated the observation by dynamic minimization of reallocation of the proteome (dMORP) using an enzyme-constrained genome-scale metabolic model, which coincided with our omics data. Moreover, we evolved strains to co-utilize mixed carbon sources and repress the choice of heterolactic fermentation, and the dynamics after co-utilization of carbon sources were also captured by dMORP. Altogether, the findings suggest that upon environmental changes, bacteria tend to minimize proteome reallocation and accordingly adjust metabolism, and dMORP would be useful in simulating cellular dynamics.IMPORTANCERedundancy in metabolic networks empowers cells to choose between distinct metabolic strategies under changing environments. However, what drives the cellular choice remains poorly understood. We hypothesized that in response to rapid environmental changes, cells might minimize reallocation of the proteome and accordingly adjust metabolism. We found that this hypothesis could interpret a metabolic transition in the lactic acid bacterium Bacillus coagulans during the hierarchical utilization of glucose and trehalose, which was validated using systems biology approaches. Furthermore, we presented a framework with the objective function of minimizing proteome allocation, allowing for the simulation and understanding of cellular responses to dynamic perturbations. äMinimization of proteome reallocation explains metabolic transition in(epmc).pdf DeepDyve Pubget Overpricing