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10.1128/msystems.00544-25 http://scihub22266oqcxt.onion/10.1128/msystems.00544-25 40586597!ä!40586597 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=40586597&cmd=llinks): Failed to open stream: HTTP request failed! 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A three-country analysis of the gut microbiome indicates taxon associations with diet vary by taxon resolution and population |pdf=|usr=}}{{40586597}} gab.com Text A three-country analysis of the gut microbiome indicates taxon associations with diet vary by taxon resolution and population JO: mSystems http://www.kidney.de/pget.php?&tw=1&pmid=40586597 #FOAvip Emerging research suggests that diet plays a vital role in shaping the composition and function of the gut microbiota. Although substantial efforts have been made to identify general patterns linking diet to the gut microbiome, much of this research has been concentrated on a small number of countries. Additionally, both diet and the gut microbiome have highly complex and individualized configurations, and there is growing evidence that tailoring diets to individual gut microbiota profiles may optimize the path toward improving or maintaining health and preventing disease. Using fecal metagenomic data from 1,177 individuals across three countries, we examine the relationship between diet and bacterial genera, focusing on Prevotella and Faecalibacterium, which have gained significant attention for their potential roles in human health and strong associations with dietary patterns. We find that these two genera in particular show significant associations with many aspects of diet but these associations vary in scale and direction, depending on the level of metagenomic resolution (i.e., genus level by reads and strain level by metagenome-assembled genomes) and the contextual population. These results highlight the growing importance of building metagenomic data sets that are standardized, comprehensive, and representative of diverse populations to increase our ability to tease apart the complex relationship between diet and the microbiome. IMPORTANCE: An analysis of fecal microbiome data from individuals in the United States, United Kingdom, and Mexico shows that associations with dietary components vary both by country and by level of resolution (i.e., genus and strain). Our work sheds light on why there may be conflicting reports regarding microbial associations with diet, disease, and health. Twit Text FOAVip A three-country analysis of the gut microbiome indicates taxon associations with diet vary by taxon resolution and population ????mSystems http://www.kidney.de/pget.php?&tw=1&pmid=40586597 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40586597 #FOAvip English Wikipedia <ref>{{Cite pmid|40586597}}</ref> A three-country analysis of the gut microbiome indicates taxon associations with diet vary by taxon resolution and population #MMPMID40586597 Khatib L; Song SJ; Dilmore AH; Sanders JG; Brennan C; Hernandez AR; Myers T; Oles R; Farmer S; Cowart C; Birmingham A; Diaz EA; Nizet O; Gilbert K; Litwin N; Das P; Nowinski B; Bryant M; Tribelhorn C; Sanders-Bodai K; Chaumont S; Knol J; Roeselers G; Laiola M; Shetty SA; Veiga P; Tap J; Derrien M; Koutnikova H; Cotillard A; Lay C; Tovar AR; Torres N; Arteaga L; Gonzalez A; McDonald D; Bartko A; Knight R mSystems 2025[Jun]; ä (ä): e0054425 PMID40586597show ga Emerging research suggests that diet plays a vital role in shaping the composition and function of the gut microbiota. Although substantial efforts have been made to identify general patterns linking diet to the gut microbiome, much of this research has been concentrated on a small number of countries. Additionally, both diet and the gut microbiome have highly complex and individualized configurations, and there is growing evidence that tailoring diets to individual gut microbiota profiles may optimize the path toward improving or maintaining health and preventing disease. Using fecal metagenomic data from 1,177 individuals across three countries, we examine the relationship between diet and bacterial genera, focusing on Prevotella and Faecalibacterium, which have gained significant attention for their potential roles in human health and strong associations with dietary patterns. We find that these two genera in particular show significant associations with many aspects of diet but these associations vary in scale and direction, depending on the level of metagenomic resolution (i.e., genus level by reads and strain level by metagenome-assembled genomes) and the contextual population. These results highlight the growing importance of building metagenomic data sets that are standardized, comprehensive, and representative of diverse populations to increase our ability to tease apart the complex relationship between diet and the microbiome. IMPORTANCE: An analysis of fecal microbiome data from individuals in the United States, United Kingdom, and Mexico shows that associations with dietary components vary both by country and by level of resolution (i.e., genus and strain). Our work sheds light on why there may be conflicting reports regarding microbial associations with diet, disease, and health. äA three-country analysis of the gut microbiome indicates taxon associa(epmc).pdf DeepDyve Pubget Overpricing