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Topical Tranexamic Acid-mediated with Non-insulated Microneedling Radiofrequency for the Treatment of Melasma |pdf=|usr=}}{{40586253}} gab.com Text Topical Tranexamic Acid-mediated with Non-insulated Microneedling Radiofrequency for the Treatment of Melasma JO: Isr Med Assoc J http://www.kidney.de/pget.php?&tw=1&pmid=40586253 #FOAvip BACKGROUND: Radiofrequency-skin interaction is considered self-limited for treating acquired pigmentation such as melasma. Alternatively, skin perforation with microneedling radiofrequency (MNRF) may increase skin bioavailability for depigmenting-mediated ingredients or drugs for the treatment of melasma. OBJECTIVES: To examine the clinical feasibility of topical tranexamic acid (TA) mediated with MNRF-assisted transepidermal delivery in patients with mixed melasma. METHODS: The study protocol included 14 women with centrofacial or malar pattern of distribution of melasma (skin types II-VI; age 35-48 years). Patients underwent four treatments at 3-week intervals between treatments. Treatment protocol included non-insulated MNFR (Intensif, EndyMed Ltd, Caesarea, Israel) followed by TA (hexakapron 4%) solution application. The improvement was evaluated based on clinical photographs (Quantificare, Biot, France) and modified Melasma Area and Severity Index (mMASI) scores. Baseline Photographs were analyzed 3 months after the last treatment. RESULTS: In 13 patients (93%), mMASI scores were significantly lower after 3 months (mean 3.6) than at baseline (5.22). In one patient, mMASI was higher at 3 months compared to baseline. Overall, mMASI improved by 31% (P < 0.01). Physician and patient satisfaction was high. Minimal adverse reactions were recorded. CONCLUSIONS: MNRF-assisted transepidermal delivery with topical TA is a safe and effective modality for the treatment of melasma. Twit Text FOAVip Topical Tranexamic Acid-mediated with Non-insulated Microneedling Radiofrequency for the Treatment of Melasma ????Isr Med Assoc J http://www.kidney.de/pget.php?&tw=1&pmid=40586253 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40586253 #FOAvip English Wikipedia <ref>{{Cite pmid|40586253}}</ref> Topical Tranexamic Acid-mediated with Non-insulated Microneedling Radiofrequency for the Treatment of Melasma #MMPMID40586253 Akerman L; Kaplan B; Mimouni D; Nosrati A; Solomon-Cohen E Isr Med Assoc J 2025[Jun]; 27 (6): 358-362 PMID40586253show ga BACKGROUND: Radiofrequency-skin interaction is considered self-limited for treating acquired pigmentation such as melasma. Alternatively, skin perforation with microneedling radiofrequency (MNRF) may increase skin bioavailability for depigmenting-mediated ingredients or drugs for the treatment of melasma. OBJECTIVES: To examine the clinical feasibility of topical tranexamic acid (TA) mediated with MNRF-assisted transepidermal delivery in patients with mixed melasma. METHODS: The study protocol included 14 women with centrofacial or malar pattern of distribution of melasma (skin types II-VI; age 35-48 years). Patients underwent four treatments at 3-week intervals between treatments. Treatment protocol included non-insulated MNFR (Intensif, EndyMed Ltd, Caesarea, Israel) followed by TA (hexakapron 4%) solution application. The improvement was evaluated based on clinical photographs (Quantificare, Biot, France) and modified Melasma Area and Severity Index (mMASI) scores. Baseline Photographs were analyzed 3 months after the last treatment. RESULTS: In 13 patients (93%), mMASI scores were significantly lower after 3 months (mean 3.6) than at baseline (5.22). In one patient, mMASI was higher at 3 months compared to baseline. Overall, mMASI improved by 31% (P < 0.01). Physician and patient satisfaction was high. Minimal adverse reactions were recorded. CONCLUSIONS: MNRF-assisted transepidermal delivery with topical TA is a safe and effective modality for the treatment of melasma. |*Antifibrinolytic Agents/administration & dosage[MESH] |*Melanosis/therapy/drug therapy[MESH] |*Tranexamic Acid/administration & dosage[MESH] |Administration, Cutaneous[MESH] |Administration, Topical[MESH] |Adult[MESH] |Feasibility Studies[MESH] |Female[MESH] |Humans[MESH] |Middle Aged[MESH] |Needles[MESH] |Percutaneous Collagen Induction[MESH] |Severity of Illness Index[MESH]Topical Tranexamic Acid-mediated with Non-insulated Microneedling Radi(epmc).pdf DeepDyve Pubget Overpricing