Colorimetric analysis of some diuretic drugs: hydrochlorothiazide and spironolactone #MMPMID4000904
Moussa BA; el Kousy NM
Pharm Weekbl Sci 1985[Apr]; 7 (2): 79-82 PMID4000904show ga
Two convenient spectrophotometric methods were developed for the determination of hydrochlorothiazide and spironolactone. A specific colour reaction for the determination of hydrochlorothiazide is reported. One method is based on the reaction of hydrochlorothiazide with n-butylamine and cobaltous chloride in anhydrous methanol. A blue-violet colour is produced and is measured at 570 nm. A highly selective colorimetric method was adopted for the analysis of spironolactone by reacting with isoniazid forming a coloured hydrazone derivative and subsequent measurement of the coloured product at 405 nm.
Pharm+Weekbl+Sci 1985 ; 7 (2): 79-82
