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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 S+Afr+Med+J 1986 ; 69 (2): 98-100 Nephropedia Template TP
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Effects of an acebutolol-hydrochlorothiazide combination on urinary solute excretion in healthy adults #MMPMID3941959
Leary WP; Reyes AJ; van der Byl K
S Afr Med J 1986[Jan]; 69 (2): 98-100 PMID3941959show ga
Ten healthy adult male volunteers were studied to assess the urinary effects of a single dose of a combination of hydrochlorothiazide 12.5 mg and acebutolol 200 mg (HZAL). The formation induced a significant increase in the 24-hour urinary output of sodium. Outputs of fluid, chloride, potassium, calcium, magnesium, zinc, total inorganic phosphate and creatinine were unaffected. With the exception of Mg2+ flow, times to maximal urinary flows of fluid and solutes were shortened by HZAL. These qualitative changes resemble those induced by hydrochlorothiazide but did not achieve quantitative significance, either because the constituent diuretic dose was too small or because acebutolol compensated for some of its effects.