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10.1099/0022-1317-66-3-503

http://scihub22266oqcxt.onion/10.1099/0022-1317-66-3-503
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3919150!ä!3919150

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suck abstract from ncbi

pmid3919150      J+Gen+Virol 1985 ; 66 ( Pt 3) (ä): 503-8
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  • Effect of Borna disease virus infection on athymic rats #MMPMID3919150
  • Herzog S; Wonigeit K; Frese K; Hedrich HJ; Rott R
  • J Gen Virol 1985[Mar]; 66 ( Pt 3) (ä): 503-8 PMID3919150show ga
  • Homozygous athymic nude rats (rnu/rnu) infected intracerebrally with Borna disease virus produced relatively high titres of infectious virus in the central nervous system. However, no clinical signs of disease or pathological alterations could be found during a 100 day observation period. In contrast, heterozygous euthymic albino littermates (rnu/+), which were used as controls, reacted in a similar manner to immunocompetent Lewis rats. They developed behavioural alterations which coincided with encephalitis and retinitis. The results obtained confirm our previous concept that the genesis of Borna disease, at least in rats, is attributed to a cellular immune response.
  • |Animals[MESH]
  • |Borna Disease/*immunology[MESH]
  • |Borna disease virus/*growth & development[MESH]
  • |Brain/microbiology[MESH]
  • |Rats[MESH]
  • |Rats, Mutant Strains[MESH]
  • |Retina/microbiology[MESH]
  • |Thymus Gland/*physiology[MESH]


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