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10.3949/ccjm.91a.23105

http://scihub22266oqcxt.onion/10.3949/ccjm.91a.23105
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39089856!ä!39089856

suck abstract from ncbi

pmid39089856      Cleve+Clin+J+Med 2024 ; 91 (8): 489-499
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  • Digoxin is still useful, but is still causing toxicity #MMPMID39089856
  • Crane AD; Militello M; Faulx MD
  • Cleve Clin J Med 2024[Aug]; 91 (8): 489-499 PMID39089856show ga
  • Digoxin, the oldest known cardiovascular drug, is still used today to treat heart failure and atrial fibrillation. Because it has a narrow therapeutic index and multiple interactions, it frequently causes toxicity with a wide range of symptoms and cardiac arrhythmias. More importantly, elevated serum digoxin levels have been linked to a higher risk of death in patients with heart failure or atrial fibrillation, even without signs or symptoms of toxicity. This article reviews the current state of digoxin use, its pharmacologic principles, and the mechanisms, clinical presentation, and management of toxicity.
  • |*Atrial Fibrillation/drug therapy[MESH]
  • |*Digoxin/adverse effects/blood[MESH]
  • |*Heart Failure/chemically induced[MESH]
  • |Anti-Arrhythmia Agents/adverse effects[MESH]
  • |Cardiotonic Agents/therapeutic use/adverse effects/pharmacology[MESH]


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