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10.1016/0042-6822(85)90460-x

http://scihub22266oqcxt.onion/10.1016/0042-6822(85)90460-x
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3880978!ä!3880978

suck abstract from ncbi


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pmid3880978      Virology 1985 ; 140 (1): 192-6
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  • Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses #MMPMID3880978
  • Dreiding P; Staeheli P; Haller O
  • Virology 1985[Jan]; 140 (1): 192-6 PMID3880978show ga
  • In mouse cells carrying the dominant influenza resistance allele Mx+ (but not in Mx- cells) interferon-alpha/beta (IFN) induces an efficient antiviral state against influenza viruses and, concomitantly, the synthesis of a 75,000-Da protein (protein Mx). Here, indirect immunofluorescence using monoclonal antibodies was used to demonstrate that protein Mx accumulates in the nucleus of IFN-treated Mx+ cells, suggesting a nuclear site of action. Protein Mx is present in the nucleus of untreated influenza virus-resistant macrophages freshly explanted from the peritoneal cavity of Mx+ mice but is lost with time in culture when peritoneal macrophages become permissive for influenza virus.
  • |*GTP-Binding Proteins[MESH]
  • |Alleles[MESH]
  • |Animals[MESH]
  • |Antibodies, Monoclonal[MESH]
  • |Cell Nucleus/metabolism[MESH]
  • |Fluorescent Antibody Technique[MESH]
  • |Immunity, Innate[MESH]
  • |Interferon Type I/*immunology[MESH]
  • |Mice[MESH]
  • |Mice, Inbred BALB C[MESH]
  • |Mice, Inbred C57BL[MESH]
  • |Mice, Inbred Strains[MESH]
  • |Myxovirus Resistance Proteins[MESH]
  • |Orthomyxoviridae/*immunology[MESH]
  • |Proteins/*genetics[MESH]


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