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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Acta+Pathol+Microbiol+Immunol+Scand+B 1985 ; 93 (3): 189-94 Nephropedia Template TP
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The influence of antimicrobial agents on macrophage-associated Staphylococcus aureus #MMPMID3875966
Nesthus I; Haneberg B; Glette J; Solberg CO
Acta Pathol Microbiol Immunol Scand B 1985[Jun]; 93 (3): 189-94 PMID3875966show ga
Macrophages obtained by culturing human blood monocytes were incubated with Staphylococcus aureus for phagocytosis to occur and exposed to gentamicin, rifampin, clindamycin or trimethoprim/sulphamethoxazole. The macrophage-associated bacteria were protected against gentamicin at low concentrations (1 mg/l) and trimethoprim/sulphamethoxazole. However, high concentrations of gentamicin and clindamycin reduced the number of bacteria, indicating that these drugs penetrated into human macrophages and killed phagocytosed bacteria. Rifampin, even at low concentrations (0.5 mg/l), caused a marked reduction in macrophage-associated bacteria, implying that the drug penetrated into the phagocytes and retained its effect in the cells most effectively.