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10.1111/j.1699-0463.1985.tb02875.x

http://scihub22266oqcxt.onion/10.1111/j.1699-0463.1985.tb02875.x
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3875966!ä!3875966

suck abstract from ncbi


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pmid3875966      Acta+Pathol+Microbiol+Immunol+Scand+B 1985 ; 93 (3): 189-94
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  • The influence of antimicrobial agents on macrophage-associated Staphylococcus aureus #MMPMID3875966
  • Nesthus I; Haneberg B; Glette J; Solberg CO
  • Acta Pathol Microbiol Immunol Scand B 1985[Jun]; 93 (3): 189-94 PMID3875966show ga
  • Macrophages obtained by culturing human blood monocytes were incubated with Staphylococcus aureus for phagocytosis to occur and exposed to gentamicin, rifampin, clindamycin or trimethoprim/sulphamethoxazole. The macrophage-associated bacteria were protected against gentamicin at low concentrations (1 mg/l) and trimethoprim/sulphamethoxazole. However, high concentrations of gentamicin and clindamycin reduced the number of bacteria, indicating that these drugs penetrated into human macrophages and killed phagocytosed bacteria. Rifampin, even at low concentrations (0.5 mg/l), caused a marked reduction in macrophage-associated bacteria, implying that the drug penetrated into the phagocytes and retained its effect in the cells most effectively.
  • |*Phagocytosis[MESH]
  • |Anti-Bacterial Agents/*pharmacology[MESH]
  • |Cells, Cultured[MESH]
  • |Clindamycin/pharmacology[MESH]
  • |Drug Combinations/pharmacology[MESH]
  • |Drug Interactions[MESH]
  • |Gentamicins/pharmacology[MESH]
  • |Humans[MESH]
  • |Macrophages/drug effects/immunology/*microbiology[MESH]
  • |Rifampin/pharmacology[MESH]
  • |Staphylococcus aureus/*drug effects/immunology[MESH]
  • |Sulfamethoxazole/pharmacology[MESH]
  • |Trimethoprim, Sulfamethoxazole Drug Combination[MESH]


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