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10.3390/v16010027 http://scihub22266oqcxt.onion/10.3390/v16010027 38257728!10821470!38257728     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=38257728&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Viruses 2023 ; 16 (1): ? Nephropedia Template TP {{tp|p=38257728|t=2023. The Functional Roles of MDSCs in Severe COVID-19 Pathogenesis |pdf=|usr=}}{{38257728}} gab.com Text The Functional Roles of MDSCs in Severe COVID-19 Pathogenesis JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=38257728 #FOAvip Severe COVID-19 is a major cause of morbidity and mortality worldwide, especially among those with co-morbidities, the elderly, and the immunocompromised. However, the molecular determinants critical for severe COVID-19 progression remain to be fully elucidated. Meta-analyses of transcriptomic RNAseq and single-cell sequencing datasets comparing severe and mild COVID-19 patients have demonstrated that the early expansion of myeloid-derived suppressor cells (MDSCs) could be a key feature of severe COVID-19 progression. Besides serving as potential early prognostic biomarkers for severe COVID-19 progression, several studies have also indicated the functional roles of MDSCs in severe COVID-19 pathogenesis and possibly even long COVID. Given the potential links between MDSCs and severe COVID-19, we examine the existing literature summarizing the characteristics of MDSCs, provide evidence of MDSCs in facilitating severe COVID-19 pathogenesis, and discuss the potential therapeutic avenues that can be explored to reduce the risk and burden of severe COVID-19. We also provide a web app where users can visualize the temporal changes in specific genes or MDSC-related gene sets during severe COVID-19 progression and disease resolution, based on our previous study. Twit Text FOAVip The Functional Roles of MDSCs in Severe COVID-19 Pathogenesis ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=38257728 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=38257728 #FOAvip English Wikipedia <ref>{{Cite pmid|38257728}}</ref> The Functional Roles of MDSCs in Severe COVID-19 Pathogenesis #MMPMID38257728 Len JS; Koh CWT; Chan KR Viruses 2023[Dec]; 16 (1): ? PMID38257728show ga Severe COVID-19 is a major cause of morbidity and mortality worldwide, especially among those with co-morbidities, the elderly, and the immunocompromised. However, the molecular determinants critical for severe COVID-19 progression remain to be fully elucidated. Meta-analyses of transcriptomic RNAseq and single-cell sequencing datasets comparing severe and mild COVID-19 patients have demonstrated that the early expansion of myeloid-derived suppressor cells (MDSCs) could be a key feature of severe COVID-19 progression. Besides serving as potential early prognostic biomarkers for severe COVID-19 progression, several studies have also indicated the functional roles of MDSCs in severe COVID-19 pathogenesis and possibly even long COVID. Given the potential links between MDSCs and severe COVID-19, we examine the existing literature summarizing the characteristics of MDSCs, provide evidence of MDSCs in facilitating severe COVID-19 pathogenesis, and discuss the potential therapeutic avenues that can be explored to reduce the risk and burden of severe COVID-19. We also provide a web app where users can visualize the temporal changes in specific genes or MDSC-related gene sets during severe COVID-19 progression and disease resolution, based on our previous study. |*COVID-19[MESH] |*Myeloid-Derived Suppressor Cells[MESH] |Aged[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Immunocompromised Host[MESH]The Functional Roles of MDSCs in Severe COVID-19 Pathogenesis (epmc).pdf DeepDyve Pubget Overpricing