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10.18632/aging.205233 http://scihub22266oqcxt.onion/10.18632/aging.205233 37988198!10713428!37988198     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=37988198&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Aging+(Albany+NY) 2023 ; 15 (22): 13176-13193 Nephropedia Template TP {{tp|p=37988198|t=2023. Investigating EGF and PAG1 as necroptosis-related biomarkers for diabetic nephropathy: an in silico and in vitro validation study |pdf=|usr=}}{{37988198}} gab.com Text Investigating EGF and PAG1 as necroptosis-related biomarkers for diabetic nephropathy: an in silico and in vitro validation study JO: Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=37988198 #FOAvip The current study aims to understand the mechanisms behind regulated cell death (RCD) in diabetic nephropathy and identify related biomarkers through bioinformatics and experimental validation. Datasets of bulk and single-cell RNA sequencing were obtained from public databases and analyzed using gene set variation analysis (GSVA) with gene sets related to RCD, including autophagy, necroptosis, pyroptosis, apoptosis, and ferroptosis. RCD-related gene biomarkers were identified using weighted gene correlation network analysis (WGCNA). The results were verified through experiments with an independent cohort and in vitro experiments. The GSVA revealed higher necroptosis scores in diabetic nephropathy. Three necroptosis-related biomarkers, EGF, PAG1, and ZFP36, were identified and showed strong diagnostic ability for diabetic kidney disease. In vitro experiments showed high levels of necroptotic markers in HK-2 cells treated with high glucose. Bioinformatics and experimental validation have thus identified EGF and PAG1 as necroptosis-related biomarkers for diabetic nephropathy. Twit Text FOAVip Investigating EGF and PAG1 as necroptosis-related biomarkers for diabetic nephropathy: an in silico and in vitro validation study ????Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=37988198 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=37988198 #FOAvip English Wikipedia <ref>{{Cite pmid|37988198}}</ref> Investigating EGF and PAG1 as necroptosis-related biomarkers for diabetic nephropathy: an in silico and in vitro validation study #MMPMID37988198 Wang Y; Zhang L; Peng Z Aging (Albany NY) 2023[Nov]; 15 (22): 13176-13193 PMID37988198show ga The current study aims to understand the mechanisms behind regulated cell death (RCD) in diabetic nephropathy and identify related biomarkers through bioinformatics and experimental validation. Datasets of bulk and single-cell RNA sequencing were obtained from public databases and analyzed using gene set variation analysis (GSVA) with gene sets related to RCD, including autophagy, necroptosis, pyroptosis, apoptosis, and ferroptosis. RCD-related gene biomarkers were identified using weighted gene correlation network analysis (WGCNA). The results were verified through experiments with an independent cohort and in vitro experiments. The GSVA revealed higher necroptosis scores in diabetic nephropathy. Three necroptosis-related biomarkers, EGF, PAG1, and ZFP36, were identified and showed strong diagnostic ability for diabetic kidney disease. In vitro experiments showed high levels of necroptotic markers in HK-2 cells treated with high glucose. Bioinformatics and experimental validation have thus identified EGF and PAG1 as necroptosis-related biomarkers for diabetic nephropathy. |*Diabetes Mellitus[MESH] |*Diabetic Nephropathies/genetics[MESH] |*Regulated Cell Death[MESH] |Adaptor Proteins, Signal Transducing[MESH] |Biomarkers[MESH] |Epidermal Growth Factor[MESH] |Humans[MESH] |Membrane Proteins[MESH]Investigating EGF and PAG1 as necroptosis-related biomarkers for diabe(epmc).pdf DeepDyve Pubget Overpricing