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10.3390/ijms242015162 http://scihub22266oqcxt.onion/10.3390/ijms242015162 37894842!10607381!37894842     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=37894842&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Int+J+Mol+Sci 2023 ; 24 (20): ? Nephropedia Template TP {{tp|p=37894842|t=2023. Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation |pdf=|usr=}}{{37894842}} gab.com Text Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=37894842 #FOAvip Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular processes like calcium homeostasis. These channels exhibit complex regulation, and one of the key regulatory mechanisms involves their interaction with calmodulin (CaM), a cytosol ubiquitous calcium-binding protein. The association between TRPM channels and CaM relies on the presence of specific CaM-binding domains in the channel structure. Upon CaM binding, the channel undergoes direct and/or allosteric structural changes and triggers down- or up-stream signaling pathways. According to current knowledge, ion channel members TRPM2, TRPM3, TRPM4, and TRPM6 are directly modulated by CaM, resulting in their activation or inhibition. This review specifically focuses on the interplay between TRPM channels and CaM and summarizes the current known effects of CaM interactions and modulations on TRPM channels in cellular physiology. Twit Text FOAVip Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=37894842 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=37894842 #FOAvip English Wikipedia <ref>{{Cite pmid|37894842}}</ref> Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation #MMPMID37894842 Vydra Bousova K; Zouharova M; Jiraskova K; Vetyskova V Int J Mol Sci 2023[Oct]; 24 (20): ? PMID37894842show ga Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular processes like calcium homeostasis. These channels exhibit complex regulation, and one of the key regulatory mechanisms involves their interaction with calmodulin (CaM), a cytosol ubiquitous calcium-binding protein. The association between TRPM channels and CaM relies on the presence of specific CaM-binding domains in the channel structure. Upon CaM binding, the channel undergoes direct and/or allosteric structural changes and triggers down- or up-stream signaling pathways. According to current knowledge, ion channel members TRPM2, TRPM3, TRPM4, and TRPM6 are directly modulated by CaM, resulting in their activation or inhibition. This review specifically focuses on the interplay between TRPM channels and CaM and summarizes the current known effects of CaM interactions and modulations on TRPM channels in cellular physiology. |*Calmodulin/metabolism[MESH] |*TRPM Cation Channels/metabolism[MESH] |Calcium Signaling[MESH] |Calcium-Binding Proteins/metabolism[MESH] |Calcium/metabolism[MESH]Interaction of Calmodulin with TRPM: An Initiator of Channel Modulatio(epmc).pdf DeepDyve Pubget Overpricing