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10.1111/j.1699-0463.1986.tb03061.x

http://scihub22266oqcxt.onion/10.1111/j.1699-0463.1986.tb03061.x
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3788573!ä!3788573

suck abstract from ncbi


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pmid3788573      Acta+Pathol+Microbiol+Immunol+Scand+B 1986 ; 94 (5): 329-32
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  • Chlamydia trachomatis: in vitro susceptibility to antibiotics singly and in combination #MMPMID3788573
  • Christensen JJ; Holten-Andersen W; Nielsen PB
  • Acta Pathol Microbiol Immunol Scand B 1986[Oct]; 94 (5): 329-32 PMID3788573show ga
  • Decreased susceptibility in vitro to erythromycin has been demonstrated for few C. trachomatis isolates outside Scandinavia, making local susceptibility-screening indicated. Eleven recent isolates of C. trachomatis found in a Danish hospital have been examined for susceptibility, expressed as minimal inhibitory concentration (MIC) to antibacterial agents commonly used in genito-urinary infections. Full susceptibility to doxycycline and erythromycin was demonstrated. Clindamycin and ampicillin showed moderate activity, and sulfamethizole had a MIC value in the border area of what is needed for therapeutic effect in non-urinary infections. C. trachomatis, being a major pathogen in pelvic inflammatory disease, makes combination chemotherapy desirable in order to protect against resistance development, to obtain synergistic effect and to ensure effect in infections of mixed etiology - provided antagonism could not be anticipated. In three checkerboard trials, with the combinations doxycycline plus ampicillin, erythromycin plus sulfamethizole and ampicillin plus sulfamethizole, using MIC as end-point, neither synergism nor antagonism could be demonstrated in the concentration range from 1/8 to 4 times the MIC values of each drug.
  • |Ampicillin/pharmacology[MESH]
  • |Anti-Bacterial Agents/*pharmacology[MESH]
  • |Chlamydia trachomatis/*drug effects[MESH]
  • |Clindamycin/pharmacology[MESH]
  • |Doxycycline/pharmacology[MESH]
  • |Drug Combinations[MESH]
  • |Erythromycin/pharmacology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Microbial Sensitivity Tests[MESH]


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