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10.1016/j.isci.2023.107916 http://scihub22266oqcxt.onion/10.1016/j.isci.2023.107916 37841588!10568349!37841588     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=37841588&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       iScience 2023 ; 26 (10): 107916 Nephropedia Template TP {{tp|p=37841588|t=2023. Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death |pdf=|usr=}}{{37841588}} gab.com Text Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=37841588 #FOAvip We identified cytoprotective small molecules (CSMs) by a cell-based high-throughput screening of Bax inhibitors. Through a medicinal chemistry program, M109S was developed, which is orally bioactive and penetrates the blood-brain/retina barriers. M109S protected retinal cells in ocular disease mouse models. M109S directly interacted with Bax and inhibited the conformational change and mitochondrial translocation of Bax. M109S inhibited ABT-737-induced apoptosis both in Bax-only and Bak-only mouse embryonic fibroblasts. M109S also inhibited apoptosis induced by staurosporine, etoposide, and obatoclax. M109S decreased maximal mitochondrial oxygen consumption rate and reactive oxygen species production, whereas it increased glycolysis. These effects on cellular metabolism may contribute to the cytoprotective activity of M109S. M109S is a novel small molecule protecting cells from mitochondria-dependent apoptosis both in vitro and in vivo. M109S has the potential to become a research tool for studying cell death mechanisms and to develop therapeutics targeting mitochondria-dependent cell death pathway. Twit Text FOAVip Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=37841588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=37841588 #FOAvip English Wikipedia <ref>{{Cite pmid|37841588}}</ref> Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death #MMPMID37841588 Matsuyama M; Ortega JT; Fedorov Y; Scott-McKean J; Muller-Greven J; Buck M; Adams D; Jastrzebska B; Greenlee W; Matsuyama S iScience 2023[Oct]; 26 (10): 107916 PMID37841588show ga We identified cytoprotective small molecules (CSMs) by a cell-based high-throughput screening of Bax inhibitors. Through a medicinal chemistry program, M109S was developed, which is orally bioactive and penetrates the blood-brain/retina barriers. M109S protected retinal cells in ocular disease mouse models. M109S directly interacted with Bax and inhibited the conformational change and mitochondrial translocation of Bax. M109S inhibited ABT-737-induced apoptosis both in Bax-only and Bak-only mouse embryonic fibroblasts. M109S also inhibited apoptosis induced by staurosporine, etoposide, and obatoclax. M109S decreased maximal mitochondrial oxygen consumption rate and reactive oxygen species production, whereas it increased glycolysis. These effects on cellular metabolism may contribute to the cytoprotective activity of M109S. M109S is a novel small molecule protecting cells from mitochondria-dependent apoptosis both in vitro and in vivo. M109S has the potential to become a research tool for studying cell death mechanisms and to develop therapeutics targeting mitochondria-dependent cell death pathway. ?Development of novel cytoprotective small compounds inhibiting mitoch(epmc).pdf DeepDyve Pubget Overpricing